THEMIS and PRMT6

Number of citations of the paper that reports this interaction (PubMedID 23455924)
46

Data Source:
BioGRID (two hybrid)

		THEMIS	PRMT6
Description		thymocyte selection associated	protein arginine methyltransferase 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cell-cell Junction COP9 Signalosome	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Protein Binding	Chromatin Binding Protein Binding Histone-arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone Methyltransferase Activity (H4-R3 Specific) Histone Methyltransferase Activity (H3-R2 Specific) Histone Methyltransferase Activity (H2A-R3 Specific)
	Biological Process	Adaptive Immune Response Positive T Cell Selection Negative T Cell Selection T Cell Receptor Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Base-excision Repair Regulation Of Mitochondrion Organization Histone Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Negative Regulation Of Histone Deacetylation Histone H3-R2 Methylation Histone H4-R3 Methylation Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Histone H3-K4 Methylation Cellular Senescence Regulation Of Signal Transduction By P53 Class Mediator
Pathways			RMTs methylate histone arginines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Asthma ( 31959851 34103634 31619474) Celiac disease ( 20190752 25920553) Crohn's disease ( 28067908) Hepcidin/ferritin ratio ( 27846281) Multiple sclerosis ( 31604244 21833088) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Post bronchodilator FEV1/FVC ratio ( 26634245) Recalcitrant atopic dermatitis ( 25935106)	Adult body size ( 32376654) Blood pressure measurement (low sodium intervention) ( 24165912) Intelligence ( 22449649) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Refractive error ( 32231278) Response to SSRI in MDD or openness ( 29559929) Restless legs syndrome ( 29029846) Sex hormone-binding globulin levels ( 22829776) Waist circumference ( 28552196) Weight ( 28552196)
Interacting Genes		1 interacting genes: PRMT6	90 interacting genes: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GPS2 GRHL3 GSTCD GTPBP2 H2AC18 H2BC21 H3-5 H3C14 H3C15 H4-16 H4C6 HESX1 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LINC02875 LOXL4 MALT1 MED28 METTL27 MLC1 MNDA MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PSMD11 PYCR3 PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WDFY3 ZNF436 ZNF557 ZSCAN9
Entrez ID		387357	55170
HPRD ID		16662	10505
Ensembl ID		ENSG00000172673	ENSG00000198890
Uniprot IDs		Q8N1K5	Q96LA8
PDB IDs			4HC4 4QPP 4QQK 4Y2H 4Y30 5E8R 5EGS 5HZM 5WCF 6P7I 6W6D 6WAD
Enriched GO Terms of Interacting Partners?
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