CENPW and CUL1

Number of citations of the paper that reports this interaction (PubMedID 29863914)
2

Data Source:
BioGRID (affinity chromatography technology, pull down)

		CENPW	CUL1
Description		centromere protein W	cullin 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleoplasm Nucleolus Nuclear Matrix	Nucleoplasm Cytosol Plasma Membrane SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Mitotic Cell Cycle Chromosome Segregation CENP-A Containing Nucleosome Assembly Chromosome Organization Cell Division Kinetochore Assembly	G1/S Transition Of Mitotic Cell Cycle Protein Monoubiquitination Cell Population Proliferation Animal Organ Morphogenesis Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Intrinsic Apoptotic Signaling Pathway
Pathways		Deposition of new CENPA-containing nucleosomes at the centromere	Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling NOTCH1 Intracellular Domain Regulates Transcription Regulation of PLK1 Activity at G2/M Transition Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling FCERI mediated NF-kB activation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Circadian Clock Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Orc1 removal from chromatin Cyclin D associated events in G1 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Neddylation Interleukin-1 signaling Iron uptake and transport Negative regulation of NOTCH4 signaling Regulation of BACH1 activity Nuclear events stimulated by ALK signaling in cancer Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Birth weight ( 31043758) Body fat percentage and type 2 diabetes (pairwise) ( 33619380) Body shape index ( 34021172) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (paediatric, total body less head) ( 24945404) Bone mineral density (paediatric, upper limb) ( 24945404) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399) Caffeine consumption from coffee or tea ( 33287642) Coronary artery disease ( 29212778) Cortical surface area (global PC1) ( 32198502) Cortical surface area (visual PC2) ( 32198502) Diastolic blood pressure ( 27841878) Feeling nervous ( 29500382) Food addiction ( 27106561) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172 25673412) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Intracranial volume ( 22504418) Intraocular pressure ( 29617998) Kidney volume ( 34128465) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Lung function (FVC) ( 30061609) Male-pattern baldness ( 29146897 27182965 28196072) Menarche (age at onset) ( 27182965 25231870) Monobrow ( 27182965) Myocardial infarction ( 33532862) Neurociticism ( 29500382) Neuroticism ( 29255261) Occipital lobe volume ( 31396565) Optic disc size ( 31809533) Pulse pressure ( 27841878) QT interval ( 29213071) Subcortical brain region volumes ( 25607358) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) Type 1 diabetes ( 30659077 30572963) Type 2 diabetes ( 30297969 32499647 28869590) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Metabolite levels ( 23823483) Uterine fibroid size (maximum volume) ( 30196971)
Interacting Genes		6 interacting genes: BTRC CENPB CENPT CUL1 H3C1 NPM1	57 interacting genes: BTRC CAND1 CDC34 CDCA3 CDK9 CDKN1B CENPE CENPW CFLAR CHEK1 CHUK CKS1B COMMD1 COPS5 COPS6 COPS8 DLEU2 E2F1 FBH1 FBXO25 FBXW11 FBXW2 FBXW4 FBXW7 GHR GPS1 HIPK2 KHNYN NEDD8 NFKBIA NFKBIB NFKBIE NLK NLRP3 NR1D2 PPP1CA PRKN PRPF40A PSMB4 PSMD4 PTTG1 RAC2 RANBP2 RBX1 RICTOR RNF7 SENP8 SKP1 SKP2 SMAD3 THRA TRIM21 UBC UBE2E3 UBE2F UBE2M ZC3HC1
Entrez ID		387103	8454
HPRD ID		16660	04389
Ensembl ID		ENSG00000203760	ENSG00000055130
Uniprot IDs		A0A0A0MRK5 Q5EE01	A0A090N7U0 B3KTW0 Q13616
PDB IDs			1LDJ 1LDK 1U6G 3RTR 3TDU 3TDZ 4F52 4P5O 5V89 6TTU 6WCQ 7B5L 7B5M 7B5N 7B5R 7B5S
Enriched GO Terms of Interacting Partners?
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