KRT7 and LAPTM5

Number of citations of the paper that reports this interaction (PubMedID 15231748)
99

Data Source:
HPRD (two hybrid)

		KRT7	LAPTM5
Description		keratin 7	lysosomal protein transmembrane 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Intermediate Filament Keratin Filament Extracellular Exosome	Lysosome Lysosomal Membrane Cytosol Integral Component Of Plasma Membrane Transport Vesicle Cytoplasmic Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin-dependent Protein Binding Protein Sequestering Activity
	Biological Process		Defense Response To Tumor Cell Positive Regulation Of Cytokine Production Involved In Immune Response Protein Targeting To Lysosome Intracellular Protein Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Induction Of Programmed Cell Death Positive Regulation Of Protein Ubiquitination Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of MAPK Cascade Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of B Cell Activation Positive Regulation Of Macrophage Cytokine Production Golgi To Lysosome Transport Positive Regulation Of Lysosomal Membrane Permeability Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Autophagic Cell Death Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Receptor Catabolic Process
Pathways		Keratinization Formation of the cornified envelope
Drugs		Primaquine Verpasep caltespen
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Diisocyanate-induced asthma ( 25918132)	Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		13 interacting genes: ATF7IP EGFR HMGB1 HSPA1A KDM1A KRT13 KRT17 KRT27 KRT5 KRT6A LAPTM5 LINC01554 UBE3A	39 interacting genes: AIG1 ANKRD13A C4orf3 CLDN19 CYB5R3 DCUN1D1 DISP1 EPN1 EPN2 EPN3 EPS15 GYPA HERC1 HEY1 HEYL HMOX2 HUWE1 INSIG2 ITCH KIR3DL3 KRT7 LDLRAD1 MRPL18 NEDD4 NEDD4L RNF168 RPRM RTP2 SLC22A2 SMURF2 TNFAIP3 TOM1L2 UBA52 UBAC1 UBC UBE2J1 USP13 VAMP1 WWP1
Entrez ID		3855	7805
HPRD ID		01014	03280
Ensembl ID		ENSG00000135480	ENSG00000162511
Uniprot IDs		P08729	Q13571 Q5TBB8
PDB IDs		4XIF
Enriched GO Terms of Interacting Partners?
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