KCNQ1 and AKAP9

Number of citations of the paper that reports this interaction (PubMedID 11799244)
251

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down)
HPRD (in vitro, in vivo)

		KCNQ1	AKAP9
Description		potassium voltage-gated channel subfamily Q member 1	A-kinase anchoring protein 9
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Early Endosome Late Endosome Endoplasmic Reticulum Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Cytoplasmic Vesicle Membrane Ion Channel Complex Neuron Projection Neuronal Cell Body Membrane Raft Ciliary Base Basolateral Part Of Cell	Golgi Apparatus Golgi Stack Cis-Golgi Network Centrosome Cytosol Cytoskeleton Voltage-gated Potassium Channel Complex Potassium Channel Complex Neuronal Cell Body Intracellular Membrane-bounded Organelle Dendritic Branch Synaptic Membrane Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Calmodulin Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein Phosphatase 1 Binding Outward Rectifier Potassium Channel Activity Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Transmembrane Transporter Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Atrial Cardiac Muscle Cell Action Potential Repolarization Scaffold Protein Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	DNA Binding Signaling Receptor Binding Protein Binding Potassium Channel Regulator Activity Protein Kinase A Regulatory Subunit Binding Transmembrane Transporter Binding Molecular Adaptor Activity
	Biological Process	Gastrin-induced Gastric Acid Secretion Glucose Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Sodium Ion Transport Heart Development Sensory Perception Of Sound Rhythmic Behavior Regulation Of Heart Contraction Regulation Of Blood Pressure Positive Regulation Of Heart Rate Gene Expression Iodide Transport Gene Silencing Cellular Chloride Ion Homeostasis Response To Insulin Response To Nicotine Social Behavior Corticosterone Secretion Inner Ear Morphogenesis Inner Ear Development Intestinal Absorption Neuromuscular Process Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Cardiac Muscle Contraction Auditory Receptor Cell Development Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Cardiac Muscle Contraction Regulation Of Gastric Acid Secretion Stomach Development Renal Absorption Cellular Response To CAMP Cellular Response To Xenobiotic Stimulus Potassium Ion Transmembrane Transport Cellular Response To Epinephrine Stimulus Adrenergic Receptor Signaling Pathway Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Cochlea Development Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Voltage-gated Sodium Channel Activity Non-motile Cilium Assembly Potassium Ion Import Across Plasma Membrane	Microtubule Nucleation Signal Transduction Negative Regulation Of Adenylate Cyclase Activity Chemical Synaptic Transmission Positive Regulation Of Microtubule Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Protein-containing Complex Localization Response To Electrical Stimulus Maintenance Of Centrosome Location Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cellular Response To CAMP Regulation Of Heart Rate By Cardiac Conduction Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Postsynaptic Neurotransmitter Receptor Activity Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Golgi Organization
Pathways		Voltage gated Potassium channels Phase 3 - rapid repolarisation Phase 2 - plateau phase	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Phase 3 - rapid repolarisation Phase 2 - plateau phase Anchoring of the basal body to the plasma membrane Signaling by BRAF and RAF1 fusions AURKA Activation by TPX2
Drugs		Enflurane Promethazine Miconazole Bepridil Dronedarone Azimilide ICA-105665 Isavuconazole
Diseases
GWAS		Birth weight ( 31043758) Blood pressure measurement (high sodium intervention) ( 24165912) Blood sugar levels ( 29403010) Body mass index ( 29381148 24861553 28892062) Childhood onset type 2 diabetes ( 33479058) Chronic kidney disease ( 29124443) Creatinine levels ( 29124443) Depressive symptoms x independent stressful life events interaction (1df test) ( 30718454) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062063 25055868) Electrocardiographic traits (multivariate) ( 32602732) Estimated glomerular filtration rate ( 31152163 31451708 29124443 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Fasting glucose ( 34059833) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Glucose homeostasis traits ( 25524916) Glycated hemoglobin levels ( 34059833 28898252) Gout ( 25967671) Height ( 28552196 20881960 25282103 25429064 31562340) Hemoglobin A1c levels ( 29403010) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hyperuricemia ( 29124443) Long QT syndrome ( 32429735) Malaria ( 31844061) Medication use (drugs used in diabetes) ( 31015401) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Mosquito bite size ( 28199695) Offspring birth weight ( 31043758) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Platelet aggregation ( 20526338) Platelet count ( 32888494) Plateletcrit ( 32888494) Protein quantitative trait loci ( 18464913) QT interval ( 23166209 30679814 29213071 24952745 19305408 19305409 29874175) Serum uric acid levels ( 29124443) T wave morphology restitution during exercise (MTAG) ( 31607149) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) Two-hour glucose ( 34059833) Type 2 diabetes ( 32794382 21573907 22885922 24509480 24101674 30054458 18711366 18711367 26961502 25102180 30297969 28254843 26818947 21799836 28406950 23945395 31118516 22961080 32499647 20581827 19401414 24390345 30718926 28869590 20174558) Urate levels ( 31578528) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 34021172 28448500) Waist-to-hip ratio adjusted for BMI ( 28552196)	Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Breast cancer ( 29059683) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Red blood cell count ( 32888494)
Interacting Genes		9 interacting genes: AKAP9 HRAS KCNE1 KCNE2 KCNE4 NUP98 PPP1CA PRKACA TRAF6	88 interacting genes: ABI2 ASB4 BEX2 BLZF1 C1orf94 CALM1 CALM2 CALM3 CASK CCDC116 CCDC146 CCP110 CDC5L CEP55 CLIC1 CSNK1D CSNK1E CTBP1 CTNNA3 DVL2 FAM90A1 FMR1 FNBP1 FXR2 GATAD1 GLIS2 GPC4 GRIN1 GTSE1 HDDC3 HNRNPM IKZF3 KCNQ1 KDM1A KIF19 KLC4 LMO1 MAGEA6 MAGED1 MED1 MYO5A NDEL1 PARD6G PCM1 PCNT PKN1 PKP2 PPP1CA PPP2R1B PPP2R3A PRC1 PRDM14 PRKAR2A PRKAR2B PRKCE RBM10 RBM14 RPA2 RSRC2 SAMD3 SCNM1 SF3B2 SGCE SLAIN1 SNF8 SNRPB SSX2 SSX3 SSX5 SUV39H2 TACC3 TCEANC TDP2 TENT5B THAP1 THOC1 TLX3 TNIK TRIP10 TSG101 TSNAX TUBGCP3 TULP3 USHBP1 USO1 VPS9D1 WAC YWHAE
Entrez ID		3784	10142
HPRD ID		06341	04921
Ensembl ID		ENSG00000053918	ENSG00000127914
Uniprot IDs		P51787 Q96AI9	A0A0A0MRF6 Q5GIA7 Q6PJH3 Q99996
PDB IDs		3BJ4 3HFC 3HFE 4UMO 4V0C 6MIE 6UZZ 6V00 6V01
Enriched GO Terms of Interacting Partners?
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