ARF4 and ITIH1

		ARF4	ITIH1
Description		ADP ribosylation factor 4	inter-alpha-trypsin inhibitor heavy chain 1
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Ruffle Membrane Dendritic Spine Extracellular Exosome Glutamatergic Synapse	Extracellular Region Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	GTPase Activity Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Protein Binding GTP Binding	Serine-type Endopeptidase Inhibitor Activity Calcium Ion Binding
	Biological Process	Protein ADP-ribosylation Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Epidermal Growth Factor Receptor Signaling Pathway Brain Development Learning Vesicle-mediated Transport Cell Migration Activation Of Phospholipase D Activity Negative Regulation Of Apoptotic Process Apical Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Transcription By RNA Polymerase II Response To Axon Injury Cilium Assembly Dendritic Spine Development Protein Localization To Cilium Regulation Of Postsynapse Organization Regulation Of Reactive Oxygen Species Metabolic Process	Negative Regulation Of Endopeptidase Activity Hyaluronan Metabolic Process
Pathways		VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs		Guanosine-5'-Diphosphate	Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 19416921 33263727 31043756) Blood protein levels ( 29875488) Body mass index ( 25673413) Body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (MOSTest) ( 32665545) General cognitive ability ( 29844566) Glaucoma (primary open-angle) ( 25173105) Osteoarthritis (hip) ( 30374069) Pulse pressure ( 30578418) Schizophrenia ( 25056061 29483656 23974872) Schizophrenia, schizoaffective disorder or bipolar disorder ( 24166486) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 34021172 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)
Interacting Genes		16 interacting genes: ADRB2 APBA1 APBA2 APBA3 COPS3 EGFR HNRNPD IKBKG ITIH1 PTEN RAB11FIP3 RCHY1 RHOA SDCBP2 SIRPA SUMO2	8 interacting genes: ARF4 ARIH2 CALR HSP90AA1 PHAX PIK3CA RBM15B SOX4
Entrez ID		378	3697
HPRD ID		03107	00927
Ensembl ID		ENSG00000168374	ENSG00000055957
Uniprot IDs		P18085	B7Z8B6 P19827
PDB IDs		1Z6X	6FPY 6FPZ
Enriched GO Terms of Interacting Partners?
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