KCNK3 and YWHAH

Number of citations of the paper that reports this interaction (PubMedID 12433946)
38

Data Source:
HPRD (in vivo, two hybrid)

		KCNK3	YWHAH
Description		potassium two pore domain channel subfamily K member 3	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Synapse	Cytoplasm Cytosol Plasma Membrane Intercalated Disc Extracellular Exosome
	Molecular Function	Ion Channel Activity Open Rectifier Potassium Channel Activity Potassium Channel Activity Protein C-terminus Binding Potassium Ion Leak Channel Activity S100 Protein Binding	Actin Binding Insulin-like Growth Factor Receptor Binding Protein Binding Sodium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding Glucocorticoid Receptor Binding Identical Protein Binding Transmembrane Transporter Binding Protein Heterodimerization Activity
	Biological Process	Potassium Ion Transport Chemical Synaptic Transmission Brain Development Response To Xenobiotic Stimulus Stabilization Of Membrane Potential Ion Transmembrane Transport Negative Regulation Of Cytosolic Calcium Ion Concentration Cellular Response To Zinc Ion Cellular Response To Hypoxia Potassium Ion Transmembrane Transport Cochlea Development	Regulation Of Sodium Ion Transport Glucocorticoid Catabolic Process Intracellular Protein Transport Signal Transduction Substantia Nigra Development Cellular Protein Localization Glucocorticoid Receptor Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Membrane Depolarization During Action Potential Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		TWIK-releated acid-sensitive K+ channel (TASK) Phase 4 - resting membrane potential	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Drugs		Doxapram Halothane	Phenethyl Isothiocyanate
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Apolipoprotein B levels ( 32203549) Body mass index ( 28892062 25673413) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Corneal astigmatism ( 29422769) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 27736895 27841878 29403010 28739976 27618452 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diverticular disease ( 30177863) Hand grip strength ( 29691431) Hematocrit ( 32888494) High light scatter reticulocyte count ( 32888494) Hypertension ( 31879980 30487518) Ischemic stroke ( 29531354) LDL cholesterol levels ( 32203549) Mean arterial pressure ( 26390057 29403010 30487518) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antihypertensives) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Parental lifespan ( 30642433) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Potassium levels ( 29403010) Pulse pressure ( 27841878 29403010 28739976 30487518 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Reticulocyte count ( 32888494) Stroke ( 29531354) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878 29403010 28739976 27618452 30487518 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Triglyceride levels ( 32203549)	Post bronchodilator FEV1 ( 26634245) Type 2 diabetes ( 30297969)
Interacting Genes		9 interacting genes: COPB1 S100A10 SFN YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	66 interacting genes: ABL1 ARHGEF28 BAD BCR BRAF CCDC125 CDC25B CDC25C CDC42 CDK16 CDKN1B CHRNA4 CREBBP EPB41L2 EPB41L3 ESR1 ESR2 EXO1 GREM1 HSPB1 ING1 KANK1 KCNH2 KCNK15 KCNK3 KCNK9 KIF5B KLC3 KRT18 MAP3K3 MAP3K5 MARK4 MDM4 MED1 MST1R NCOA1 NCOA2 NCOA3 NEK1 NHSL2 NR3C1 NRIP1 PARD3 PARD6A PARD6B PDPK1 PRKCI PRKN PTH1R RAF1 REM1 RIMS1 RIMS2 RPH3A SAMSN1 SNCA SRC THRA TLX2 TNFAIP3 TPH1 TSC1 TSC2 YWHAE YWHAG ZFP36
Entrez ID		3777	7533
HPRD ID		04451	00215
Ensembl ID		ENSG00000171303	ENSG00000128245
Uniprot IDs		O14649	A0A024R1K7 Q04917 Q9H4N8
PDB IDs		6RV2 6RV3 6RV4	2C63 2C74
Enriched GO Terms of Interacting Partners?
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