KCNJ9 and DRD4

Number of citations of the paper that reports this interaction (PubMedID 12297500)
49

Data Source:
HPRD (in vitro, in vivo)

		KCNJ9	DRD4
Description		potassium inwardly rectifying channel subfamily J member 9	dopamine receptor D4
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Membrane Dendrite Postsynapse Glutamatergic Synapse
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding G-protein Activated Inward Rectifier Potassium Channel Activity	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Dopamine Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Potassium Channel Regulator Activity SH3 Domain Binding Neurotransmitter Receptor Activity Dopamine Binding Identical Protein Binding Metal Ion Binding Epinephrine Binding Norepinephrine Binding
	Biological Process	Regulation Of Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane	Behavioral Fear Response Synaptic Transmission, Dopaminergic Response To Amphetamine Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Chemical Synaptic Transmission Adult Locomotory Behavior Positive Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Kinase Activity Response To Histamine Social Behavior Regulation Of Dopamine Metabolic Process Dopamine Metabolic Process Fear Response Regulation Of Circadian Rhythm Positive Regulation Of MAP Kinase Activity Behavioral Response To Cocaine Behavioral Response To Ethanol Rhythmic Process Arachidonic Acid Secretion Negative Regulation Of Protein Secretion Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Inhibitory Postsynaptic Potential G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Voltage-gated Calcium Channel Activity
Pathways		Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Dopamine receptors G alpha (i) signalling events
Drugs		Ethanol Isavuconazole	Ziprasidone Cabergoline Ropinirole Olanzapine Clozapine Loxapine Remoxipride Pramipexole Chlorpromazine Buspirone Amoxapine Lisuride Apomorphine Dopamine Ergoloid mesylate Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Paliperidone Methotrimeprazine Flibanserin Iloperidone Rotigotine Asenapine Sumanirole Perospirone Pipamperone Epicriptine Pardoprunox Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Alcohol consumption over the past year ( 29058377)
Interacting Genes		7 interacting genes: ADRB2 ATP6V1A DRD2 DRD4 KCNJ3 KCNJ6 TMEM201	13 interacting genes: ADCY2 ADRB2 CARS1 CLIC6 ETNK1 GABRA1 GNAI1 GRB2 KCNJ9 KIF2C KLHL12 MKI67 NCK1
Entrez ID		3765	1815
HPRD ID		02959	00541
Ensembl ID		ENSG00000162728	ENSG00000069696
Uniprot IDs		Q92806	P21917
PDB IDs		6X23	5WIU 5WIV
Enriched GO Terms of Interacting Partners?
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