KCND3 and KCNIP2

Number of citations of the paper that reports this interaction (PubMedID 12928444)
12

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		KCND3	KCNIP2
Description		potassium voltage-gated channel subfamily D member 3	potassium voltage-gated channel interacting protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Postsynaptic Density Integral Component Of Membrane Sarcolemma Neuronal Cell Body Dendritic Spine Postsynaptic Membrane GABA-ergic Synapse Integral Component Of Postsynaptic Specialization Membrane	Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Potassium Channel Complex Synapse
	Molecular Function	Voltage-gated Potassium Channel Activity A-type (transient Outward) Potassium Channel Activity Protein Binding Transmembrane Transporter Binding Metal Ion Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	A-type (transient Outward) Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Transmembrane Transporter Binding ER Retention Sequence Binding Protein N-terminus Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Potassium Ion Transport Regulation Of Ion Transmembrane Transport Protein Homooligomerization Potassium Ion Transmembrane Transport Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization	Detection Of Calcium Ion Potassium Ion Transport Muscle Contraction Signal Transduction Chemical Synaptic Transmission Regulation Of Heart Contraction Clustering Of Voltage-gated Potassium Channels Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Potassium Ion Export Across Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Voltage-gated Potassium Channel Activity
Pathways		Voltage gated Potassium channels Phase 1 - inactivation of fast Na+ channels	Phase 1 - inactivation of fast Na+ channels
Drugs		Enflurane Disopyramide Imipramine Promethazine Miconazole Nifedipine Dronedarone Vernakalant Dalfampridine Isavuconazole
Diseases
GWAS		Adult body size ( 32376654) Atrial fibrillation ( 28416822 30061737 29892015) Early cardiac repolarization ( 31600170 22683750) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Medication use (opioids) ( 31015401) Multisite chronic pain ( 33830993 31194737) P wave duration ( 24850809) P wave terminal force ( 28794112) PR interval ( 30679814 32439900) Response to radiotherapy in cancer (late toxicity) ( 24785509) TPE interval (resting) ( 32386560) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Visceral adipose tissue adjusted for BMI ( 22589738)	Raw vegetable consumption ( 32066663)
Interacting Genes		2 interacting genes: KCNIP1 KCNIP2	5 interacting genes: GOLGA7 KCND2 KCND3 KCNIP1 SYCE1L
Entrez ID		3752	30819
HPRD ID		16104	06880
Ensembl ID		ENSG00000171385	ENSG00000120049
Uniprot IDs		A0A024R0C6 Q9UK17	A0A2R8Y6D7 B3KSZ5 Q9NS61
PDB IDs		1S1G 2NZ0
Enriched GO Terms of Interacting Partners?
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