HDDC3 and TPM3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		HDDC3	TPM3
Description		HD domain containing 3	tropomyosin 3
Image
GO Annotations	Cellular Component		Stress Fiber Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton Extracellular Exosome
	Molecular Function	Protein Binding Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase Activity Metal Ion Binding	Molecular_function Protein Binding Actin Filament Binding
	Biological Process		Muscle Contraction Actin Filament Organization
Pathways			Striated Muscle Contraction Smooth Muscle Contraction RHOV GTPase cycle Signaling by ALK fusions and activated point mutants
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS			Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cooked vegetable consumption ( 32066663) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010 32888494) Mean reticulocyte volume ( 32888494) Platelet count ( 27863252) Smoking initiation (ever regular vs never regular) ( 30679032) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		15 interacting genes: AKAP9 APP CCDC172 CCHCR1 CEP57L1 EXOC5 GKAP1 GOLGA8EP GOLGA8F KIF7 MAGEA4 MSTO1 NMI TNIP1 TPM3	59 interacting genes: ACTA1 ACTB BLOC1S6 C1orf216 CAVIN3 CCDC102B CCDC146 CCHCR1 CHRM3 CNN1 DVL2 FAM9C FBXO5 FGA HDDC3 HOOK2 HSF2 HSF4 IFIT3 IKBIP KCNE1 KIFC3 KXD1 LCA5L LURAP1 MAD1L1 MAGEA11 MAST2 NEK2 NOD2 NUP54 ODAD1 OIP5 PBX3 PHLDB3 PSMC5 S100A2 S100A4 SMAD3 SNAPIN SUMO4 SYCE1 TAB2 TFPT THAP1 THAP7 TLK1 TMOD1 TMOD2 TNNI1 TNNT1 TPM4 TRAP1 TRIM27 TRIP6 TSKS VPS52 WASH3P WASHC1
Entrez ID		374659	7170
HPRD ID		14635	01840
Ensembl ID		ENSG00000184508	ENSG00000143549
Uniprot IDs		Q8N4P3	A0A087WWU8 A0A0S2Z4G4 A0A0S2Z4I4 B4DQ80 P06753
PDB IDs		3NR1 5VXA	6OTN
Enriched GO Terms of Interacting Partners?
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