HiPPIP
Home
About
SZ Genes
People
Help
Advanced Search
JAK2 and TSHR
Number of citations of the paper that reports this interaction (PubMedID
10809230
)
14
Data Source:
HPRD
(in vivo)
JAK2
TSHR
Description
Janus kinase 2
thyroid stimulating hormone receptor
Image
GO Annotations
Cellular Component
Euchromatin
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Caveola
Focal Adhesion
Endosome Lumen
Membrane Raft
Postsynapse
Glutamatergic Synapse
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Basolateral Plasma Membrane
Receptor Complex
Molecular Function
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Growth Hormone Receptor Binding
Interleukin-12 Receptor Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
Protein Kinase Binding
Heme Binding
Type 1 Angiotensin Receptor Binding
Acetylcholine Receptor Binding
Histone Kinase Activity (H3-Y41 Specific)
SH2 Domain Binding
Histone Binding
Identical Protein Binding
Phosphatidylinositol 3-kinase Binding
Insulin Receptor Substrate Binding
Metal Ion Binding
Peptide Hormone Receptor Binding
Thyroid-stimulating Hormone Receptor Activity
Protein Binding
G Protein-coupled Peptide Receptor Activity
Signaling Receptor Activity
Protein-containing Complex Binding
Biological Process
Microglial Cell Activation
Adaptive Immune Response
Protein Phosphorylation
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Receptor Signaling Pathway Via JAK-STAT
Tyrosine Phosphorylation Of STAT Protein
Mesoderm Development
Negative Regulation Of Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Positive Regulation Of Platelet Activation
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Cell-substrate Adhesion
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Negative Regulation Of Cell-cell Adhesion
Actin Filament Polymerization
Cell Differentiation
Erythrocyte Differentiation
Positive Regulation Of Cell Migration
Axon Regeneration
Mineralocorticoid Receptor Signaling Pathway
Positive Regulation Of Insulin Secretion
Response To Lipopolysaccharide
Positive Regulation Of Phosphoprotein Phosphatase Activity
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Tumor Necrosis Factor Production
Response To Hydroperoxide
Tumor Necrosis Factor-mediated Signaling Pathway
Response To Tumor Necrosis Factor
Histone H3-Y41 Phosphorylation
Intracellular Signal Transduction
Interleukin-12-mediated Signaling Pathway
Collagen-activated Signaling Pathway
Positive Regulation Of Protein Import Into Nucleus
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Activation Of Janus Kinase Activity
Regulation Of Apoptotic Process
Positive Regulation Of DNA Binding
Negative Regulation Of DNA Binding
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of MHC Class II Biosynthetic Process
Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Cell Differentiation
Negative Regulation Of Heart Contraction
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Response To Antibiotic
Protein Autophosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Modulation Of Chemical Synaptic Transmission
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Interferon-gamma-mediated Signaling Pathway
Positive Regulation Of SMAD Protein Signal Transduction
Growth Hormone Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Growth Hormone Receptor Signaling Pathway
Mammary Gland Epithelium Development
Interleukin-6-mediated Signaling Pathway
Response To Interleukin-12
Interleukin-35-mediated Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Postsynapse To Nucleus Signaling Pathway
Positive Regulation Of Cold-induced Thermogenesis
Positive Regulation Of Platelet Aggregation
Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation
Positive Regulation Of Epithelial Cell Apoptotic Process
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Signaling Receptor Activity
Cell Surface Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Activation Of Adenylate Cyclase Activity
Cell-cell Signaling
Positive Regulation Of Cell Population Proliferation
Hormone-mediated Signaling Pathway
Thyroid-stimulating Hormone Signaling Pathway
Positive Regulation Of Cold-induced Thermogenesis
Cellular Response To Glycoprotein
Cellular Response To Thyrotropin-releasing Hormone
Pathways
Interleukin-6 signaling
Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
Prolactin receptor signaling
Prolactin receptor signaling
Signaling by SCF-KIT
Signaling by Leptin
RMTs methylate histone arginines
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF activation
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
IL-6-type cytokine receptor ligand interactions
Signaling by moderate kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Cyclin D associated events in G1
Interferon gamma signaling
Regulation of IFNG signaling
Regulation of IFNG signaling
Interleukin-20 family signaling
Interleukin-35 Signalling
Signaling by Erythropoietin
Interleukin-12 signaling
Interleukin-12 signaling
Interleukin-23 signaling
Interleukin-23 signaling
Interleukin-27 signaling
Interleukin-27 signaling
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phospholipase C gamma (PLCG)
Erythropoietin activates STAT5
Erythropoietin activates RAS
Erythropoietin activates RAS
Interleukin receptor SHC signaling
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by CSF3 (G-CSF)
Signaling by CSF3 (G-CSF)
Potential therapeutics for SARS
Inactivation of CSF3 (G-CSF) signaling
Inactivation of CSF3 (G-CSF) signaling
Growth hormone receptor signaling
Growth hormone receptor signaling
Factors involved in megakaryocyte development and platelet production
Hormone ligand-binding receptors
G alpha (s) signalling events
ADORA2B mediated anti-inflammatory cytokines production
Drugs
2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one
XL019
5-phenyl-1H-indazol-3-amine
4-(3-amino-1H-indazol-5-yl)-N-tert-butylbenzenesulfonamide
4-[(2-{4-[(CYCLOPROPYLCARBAMOYL)AMINO]-1H-PYRAZOL-3-YL}-1H-BENZIMIDAZOL-6-YL)METHYL]MORPHOLIN-4-IUM
Ruxolitinib
Tofacitinib
Baricitinib
Entrectinib
Fostamatinib
Fedratinib
Zanubrutinib
Pralsetinib
Thyrotropin alfa
Diseases
GWAS
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
18587394
21102463
23266558
)
Eosinophil counts (
32888494
27863252
)
Eosinophil percentage of white cells (
32888494
)
HDL cholesterol (
30275531
)
Height (
31562340
)
Inflammatory bowel disease (
23128233
)
LDL cholesterol (
30275531
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte percentage of white cells (
32888494
)
Myeloproliferative neoplasms (
19287384
25849990
33057200
)
Neutrophil count (
32888494
)
Pediatric autoimmune diseases (
26301688
)
Platelet count (
32888494
27863252
24777453
28031487
)
Plateletcrit (
32888494
27863252
)
Psoriatic arthritis (
26626624
)
Red blood cell count (
32888494
)
Sum eosinophil basophil counts (
27863252
)
Systemic lupus erythematosus (
27399966
33272962
)
Total cholesterol levels (
30275531
)
Ulcerative colitis (
19915573
26398853
20228799
21297633
)
White blood cell count (
32888494
)
Graves' disease (
21841780
22922229
)
Hair morphology (
19896111
)
Male sexual orientation (
29217827
)
Maximal oxygen uptake response (
25729143
)
Obstetric antiphospholipid syndrome (
28424481
)
Optic nerve measurement (rim area) (
20395239
)
Smooth-surface caries (
24556642
)
Thyroid stimulating hormone levels (
30367059
32769997
)
Tourette syndrome (
30818990
)
Uric acid levels (
21294900
)
Urinary albumin excretion (
32277301
)
Visceral fat (
22589738
)
Interacting Genes
98 interacting genes:
ABL1
AGTR1
ARL11
ASS1
BCR
BRCA1
CBL
CCR5
CRLF2
CSF2RB
CSF3R
CTLA4
CXCR4
DNAJA3
EGFR
ELP2
EPOR
ERBB2
ERBB3
EZH2
FES
FYN
GHR
GRB10
GRB2
GTF2I
H3-4
HES1
HES5
HSFY1
HSPA8
HTR2A
IFNGR1
IFNGR2
IGF1R
IKBKG
IL12RB2
IL23R
IL3RA
IL4R
IL5RA
INSR
IRS1
IRS2
JAK1
JAK3
KIT
LEPR
LYN
MAP3K5
MDK
MPL
MST1R
NFKBIA
OSMR
PDGFRB
PIK3R1
PKD1
PLCG2
PPIA
PPP1CC
PPP2CA
PPP2R1B
PPP2R5A
PRLR
PRMT5
PTK2
PTK2B
PTPN1
PTPN11
PTPN12
PTPN6
PTPRC
RAF1
RBMX
SH2B1
SH2B2
SHC1
SIRPA
SOCS1
SOCS3
STAM
STAM2
STAP2
STAT1
STAT2
STAT3
STAT5A
STAT5B
TEC
TNFRSF1A
TRAF6
TSHR
TUB
UBASH3B
VAV1
VCP
YES1
38 interacting genes:
ACTB
ADORA1
ADRB2
ASPHD1
BNIP1
CALR
CANX
CD81
CRADD
FLNB
FN1
GNA11
GNA12
GNA13
GNAI1
GNAI2
GNAI3
GNAO1
GNAQ
GNAS
HNRNPA1
HSPA5
JAK1
JAK2
JPH3
LHCGR
MID1IP1
MOG
PIK3R1
PTDSS1
RABAC1
RUNDC3A
SCRIB
STAT3
SYT1
TMCO3
TMEM119
TSHB
Entrez ID
3717
7253
HPRD ID
00993
04537
Ensembl ID
ENSG00000096968
ENSG00000165409
Uniprot IDs
A8K910
B4DYV1
O60674
A0A0A0MTJ0
P16473
PDB IDs
2B7A
2W1I
2XA4
3E62
3E63
3E64
3FUP
3IO7
3IOK
3JY9
3KCK
3KRR
3LPB
3Q32
3RVG
3TJC
3TJD
3UGC
3ZMM
4AQC
4BBE
4BBF
4C61
4C62
4D0W
4D0X
4D1S
4E4M
4E6D
4E6Q
4F08
4F09
4FVP
4FVQ
4FVR
4GFM
4GMY
4HGE
4IVA
4JI9
4JIA
4P7E
4YTC
4YTF
4YTH
4YTI
4Z32
4ZIM
5AEP
5CF4
5CF5
5CF6
5CF8
5HEZ
5I4N
5L3A
5TQ3
5TQ4
5TQ5
5TQ6
5TQ7
5TQ8
5USY
5USZ
5UT0
5UT1
5UT2
5UT3
5UT4
5UT5
5UT6
5WEV
5WIJ
5WIK
5WIL
5WIM
5WIN
6AAJ
6BBV
6BRW
6BS0
6BSS
6D2I
6DRW
6E2P
6E2Q
6G3C
6M9H
6OAV
6OBB
6OBF
6OBL
6OCC
6TPD
6VGL
6VN8
6VNB
6VNC
6VNE
6VNF
6VNG
6VNH
6VNI
6VNJ
6VNK
6VNL
6VNM
6VS3
6VSN
6X8E
6XJK
1XUM
2XWT
3G04
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?