ITPR3 and TRPM2

Number of citations of the paper that reports this interaction (PubMedID 11290752)
84

Data Source:
HPRD (in vitro)

		ITPR3	TRPM2
Description		inositol 1,4,5-trisphosphate receptor type 3	transient receptor potential cation channel subfamily M member 2
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GO Annotations	Cellular Component	Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Brush Border Membrane Sarcoplasmic Reticulum Cytoplasmic Vesicle Membrane Secretory Granule Membrane Platelet Dense Tubular Network Membrane Neuronal Cell Body Myelin Sheath Receptor Complex Apical Part Of Cell	Lysosome Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle Membrane Specific Granule Membrane Neuron Projection Perikaryon Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Inositol Hexakisphosphate Binding Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Calcium Ion Binding Protein Binding Calcium-release Channel Activity Phosphatidylinositol Binding Inositol 1,3,4,5 Tetrakisphosphate Binding Inositol 1,4,5 Trisphosphate Binding	Cation Channel Activity Calcium Channel Activity Sodium Channel Activity Manganese Ion Transmembrane Transporter Activity Calcium Ion Binding Calcium-release Channel Activity Hydrolase Activity ADP-ribose Diphosphatase Activity Mono-ADP-D-ribose Binding Ligand-gated Calcium Channel Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Memory Inositol Phosphate-mediated Signaling Sensory Perception Of Bitter Taste Sensory Perception Of Sweet Taste Sensory Perception Of Umami Taste Release Of Sequestered Calcium Ion Into Cytosol Response To Calcium Ion Long-term Synaptic Potentiation Calcium Ion Transport Into Cytosol	Temperature Homeostasis Dendritic Cell Chemotaxis Calcium Ion Transport Response To Heat Response To Purine-containing Compound Positive Regulation Of Insulin Secretion Response To Hydroperoxide Calcium-mediated Signaling Using Intracellular Calcium Source Sodium Ion Transmembrane Transport Estrous Cycle Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Regulation Of Filopodium Assembly Cellular Response To Hydrogen Peroxide Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To Purine-containing Compound Manganese Ion Transmembrane Transport Cellular Response To Temperature Stimulus Zinc Ion Transmembrane Transport Dendritic Cell Differentiation Calcium Ion Transmembrane Import Into Cytosol Cation Transmembrane Transport Calcium Ion Import Across Plasma Membrane Positive Regulation Of Oxidative Stress-induced Neuron Death Regulation Of Actin Cytoskeleton Reorganization
Pathways		PLC beta mediated events Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Ca2+ pathway Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	TRP channels Neutrophil degranulation
Drugs		Caffeine
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma and attention deficit hyperactivity disorder ( 31619474) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 23850713) Educational attainment ( 23722424) Hodgkin's lymphoma ( 30194254) Multiple sclerosis and body mass index (pleiotropy) ( 26920376) Obesity (extreme) ( 19553259) Phosphorus levels ( 20558539) Regular attendance at a gym or sports club ( 29970889) Total carotid plaque area (excess vs minimal atherosclerosis) ( 32811377) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Anorectal malformation ( 31136621) Dental caries (decayed, missing and filled teeth) ( 31533690) Parkinson's disease ( 32201043)
Interacting Genes		18 interacting genes: AKT1 ANK1 BAP1 BECN1 CABP1 ITPR1 MTDH MTNR1A MTNR1B SIGMAR1 TRPC1 TRPC2 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM2	4 interacting genes: EFHC1 ITPR3 TRAPPC10 TRPC6
Entrez ID		3710	7226
HPRD ID		00926	04777
Ensembl ID		ENSG00000096433	ENSG00000142185
Uniprot IDs		A6H8K3 Q14573 Q59ES2	B4DVI8 O94759 Q14DR2
PDB IDs		6DQJ 6DQN 6DQS 6DQV 6DQZ 6DR0 6DR2 6DRA 6DRC 6UQK	6MIX 6MIZ 6MJ2 6PUO 6PUR 6PUS 6PUU
Enriched GO Terms of Interacting Partners?
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