ITGAM and DKK4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ITGAM	DKK4
Description		integrin subunit alpha M	dickkopf WNT signaling pathway inhibitor 4
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integrin Complex External Side Of Plasma Membrane Cell Surface Integrin AlphaM-beta2 Complex Specific Granule Membrane Plasma Membrane Raft Extracellular Exosome Tertiary Granule Membrane	Cellular_component Extracellular Space
	Molecular Function	Amyloid-beta Binding Complement Component C3b Binding Integrin Binding Protein Binding Heat Shock Protein Binding Cargo Receptor Activity Metal Ion Binding	Molecular_function Protein Binding Co-receptor Binding Receptor Antagonist Activity
	Biological Process	Microglial Cell Activation Receptor-mediated Endocytosis Phagocytosis, Engulfment Cell Adhesion Integrin-mediated Signaling Pathway Ectodermal Cell Differentiation Forebrain Development Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Neutrophil Degranulation Innate Immune Response Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Protein Targeting To Membrane Apoptotic Signaling Pathway Amyloid-beta Clearance Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Hippocampal Neuron Apoptotic Process Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning Positive Regulation Of Neuron Death Positive Regulation Of Microglial Cell Mediated Cytotoxicity Cell Surface Receptor Signaling Pathway Involved In Cell-cell Signaling Positive Regulation Of Prostaglandin-E Synthase Activity	Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Hair Follicle Placode Formation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signaling Receptor Activity
Pathways		Toll Like Receptor 4 (TLR4) Cascade Cell surface interactions at the vascular wall Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation	TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Signaling by LRP5 mutants
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Graves' disease ( 22922229) IgA nephropathy ( 25305756) Serum metabolite levels (CMS) ( 31636271) Systemic lupus erythematosus ( 27399966 18204446 24871463 26606652 23273568 26502338 18204098 21408207 32771030 19165918 28714469 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Interacting Genes		56 interacting genes: ABHD16A AQP6 ARL13B AUP1 C3 CD209 CD79A CERS4 CFH CLEC4M CLRN1 CREB3L1 DKK4 ELANE ELOVL4 ERGIC3 FGG GJA8 GJB1 GORAB GP1BA GPR42 HP HSD17B13 ICAM1 ICAM2 ICAM4 IRAK1 ITGB2 JAM3 KASH5 KCNJ6 KIR2DL3 LMNA MGST3 MMGT1 MRM1 MUC1 PGRMC2 PIGP PLAUR REEP2 REEP4 RUSF1 SCN3B SHARPIN SLC10A6 SLC35C2 SYT2 THY1 TMEM14B TMEM229B TMEM31 TMEM52B TMX2 TYMS	4 interacting genes: GIMAP5 ITGAM NRG1 TSPO2
Entrez ID		3684	27121
HPRD ID		00411	05660
Ensembl ID		ENSG00000169896	ENSG00000104371
Uniprot IDs		P11215	Q9UBT3
PDB IDs		1A8X 1BHO 1BHQ 1IDN 1IDO 1JLM 1M1U 1MF7 1N9Z 1NA5 2LKE 2LKJ 3Q3G 3QA3 4M76 4XW2 6RHW	5O57
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?