ABCC6 and CRYL1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		ABCC6	CRYL1
Description		ATP binding cassette subfamily C member 6	crystallin lambda 1
Image
GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane	Cytosol Extracellular Exosome
	Molecular Function	Transporter Activity ATP Binding ABC-type Xenobiotic Transporter Activity ABC-type Glutathione S-conjugate Transporter Activity Inorganic Diphosphate Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity	Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Homodimerization Activity L-gulonate 3-dehydrogenase Activity NAD+ Binding
	Biological Process	Xenobiotic Transmembrane Transport Visual Perception Response To Xenobiotic Stimulus ATP Transport Inorganic Diphosphate Transport Cellular Phosphate Ion Homeostasis Xenobiotic Transport Transmembrane Transport Leukotriene Transport	Fatty Acid Metabolic Process
Pathways		ABC-family proteins mediated transport Defective ABCC6 causes PXE	Formation of xylulose-5-phosphate
Drugs		ATP
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Multiple myeloma (survival) ( 26198393) Red blood cell count ( 32888494)	Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) ( 23648065) Obesity-related traits ( 23251661)
Interacting Genes		5 interacting genes: A1BG AK2 CRYL1 FURIN NR4A1	1 interacting genes: ABCC6
Entrez ID		368	51084
HPRD ID		04453	16762
Ensembl ID		ENSG00000091262	ENSG00000165475
Uniprot IDs		O95255	Q9Y2S2 V9HWG2
PDB IDs		6BZR 6BZS 6NLO 6P7F	3F3S
Enriched GO Terms of Interacting Partners?
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