ITGA1 and COL13A1

Number of citations of the paper that reports this interaction (PubMedID 10713152)
42

Data Source:
HPRD (in vivo)

		ITGA1	COL13A1
Description		integrin subunit alpha 1	collagen type XIII alpha 1 chain
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin Alpha1-beta1 Complex Neuron Projection Perikaryon Membrane Raft Basal Part Of Cell Extracellular Exosome	Extracellular Region Collagen Trimer Collagen Type XIII Trimer Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Cell-cell Junction Extracellular Matrix Postsynaptic Membrane Collagen-containing Extracellular Matrix
	Molecular Function	Signaling Receptor Binding Protein Binding Collagen Binding Protein Phosphatase Binding Metal Ion Binding Collagen Binding Involved In Cell-matrix Adhesion	Extracellular Matrix Structural Constituent Protein Binding Heparin Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Cell-matrix Adhesion Integrin-mediated Signaling Pathway Negative Regulation Of Cell Population Proliferation Neutrophil Chemotaxis Positive Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vasodilation Positive Regulation Of Neuron Apoptotic Process Cellular Extravasation Neuron Projection Morphogenesis	Skeletal System Development Morphogenesis Of A Branching Structure Endochondral Ossification Cell-matrix Adhesion Cell Differentiation Extracellular Matrix Organization Collagen Fibril Organization Notochord Development Cell-cell Adhesion
Pathways		Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Other semaphorin interactions Smooth Muscle Contraction CHL1 interactions Platelet Adhesion to exposed collagen	Collagen degradation Collagen biosynthesis and modifying enzymes Integrin cell surface interactions Collagen chain trimerization
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Alanine aminotransferase levels ( 33547301) Alzheimer's disease biomarkers ( 23419831) Apolipoprotein B levels ( 32203549) Attention deficit hyperactivity disorder ( 28809852) Chronic obstructive pulmonary disease ( 30804561) Coronary artery disease ( 26708285) FEV1 ( 30804560) Gamma glutamyl transferase levels ( 29403010 33339817) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 22001757) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FEV1/FVC) ( 28166213 30804560) Metabolite levels ( 23823483) Myocardial infarction ( 26708285) Peak expiratory flow ( 30804560) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Pulse pressure ( 30224653 30578418) Red blood cell count ( 32888494) Response to platinum-based agents ( 22020760) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum alkaline phosphatase levels ( 33547301) Serum thyroid-stimulating hormone levels ( 25436638) Serum total protein level ( 29403010) Total cholesterol levels ( 30275531) Type 2 diabetes ( 30297969 30130595 32499647 30718926 29926116) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)	Adverse response to drug ( 30420678) Antidepressant treatment resistance (number of drugs prescribed) ( 30700811) Carboplatin disposition in epthelial ovarian cancer ( 29367611) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Early childhood aggressive behavior ( 26087016) Middle childhood and early adolescence aggressive behavior ( 26087016) Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Optic disc size ( 31809533) Parkinson's disease ( 23793441) PR interval ( 32439900) Response to fenofibrate (total cholesterol levels) ( 27002377) Triglyceride levels in HIV infection ( 33109212) Ulcerative colitis ( 25082827) Upper eyelid morphology ( 29921221)
Interacting Genes		10 interacting genes: AUP1 BIN1 COL13A1 COL8A1 ITGB1 LAMA1 MATN1 PTPN2 SHARPIN TLN1	7 interacting genes: FN1 HSPG2 ITGA1 MTDH NID1 NID2 SPARC
Entrez ID		3672	1305
HPRD ID		01892	00383
Ensembl ID		ENSG00000213949	ENSG00000197467
Uniprot IDs		P56199	Q5TAT6
PDB IDs		1PT6 1QC5 1QCY 2L8S 2M32 4A0Q 5HGJ
Enriched GO Terms of Interacting Partners?
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