PDX1 and SLC2A2

Number of citations of the paper that reports this interaction (PubMedID 8923459)
77

Data Source:
HPRD (in vivo)

		PDX1	SLC2A2
Description		pancreatic and duodenal homeobox 1	solute carrier family 2 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Nuclear Speck	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Brush Border Cell-cell Junction Membrane Apical Plasma Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein-containing Complex Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	Fructose Transmembrane Transporter Activity Glucose Transmembrane Transporter Activity Hexose Transmembrane Transporter Activity Dehydroascorbic Acid Transmembrane Transporter Activity D-glucose Transmembrane Transporter Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Liver Development Type B Pancreatic Cell Differentiation Glucose Metabolic Process Generation Of Precursor Metabolites And Energy Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Smoothened Signaling Pathway Nitric Oxide Mediated Signal Transduction Central Nervous System Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Wounding Animal Organ Morphogenesis Response To Iron(II) Ion Response To Chlorate Animal Organ Senescence Positive Regulation Of Cell Death Morphogenesis Of Embryonic Epithelium Insulin Secretion Exocrine Pancreas Development Animal Organ Regeneration Response To Vitamin Response To Cytokine Response To Nicotine Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Glucose Homeostasis Response To Leucine Response To Alkaloid Positive Regulation Of DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Stem Cell Differentiation Response To Glucocorticoid Detection Of Glucose Transdifferentiation Response To Fatty Acid Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Apoptotic Process	Carbohydrate Metabolic Process Fructose Transmembrane Transport Dehydroascorbic Acid Transport Glucose Transmembrane Transport
Pathways		Regulation of gene expression in beta cells Regulation of gene expression in early pancreatic precursor cells	Cellular hexose transport Regulation of gene expression in beta cells Regulation of insulin secretion Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) Intestinal hexose absorption
Drugs			Streptozocin
Diseases
GWAS		Acute insulin response ( 28490609) Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 33547301) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Birth weight ( 31043758) Blood sugar levels ( 29403010) Body mass index ( 26426971) Fasting blood glucose ( 25631608 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 33402679) Fasting plasma glucose ( 28270201) Glycated hemoglobin levels ( 28898252) Pancreatic cancer ( 29422604 26098869 25086665) Peak insulin response ( 28490609)	Adult body size ( 32376654) Alanine aminotransferase levels ( 33547301) Blood sugar levels ( 29403010) C-reactive protein levels ( 30388399) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 33402679 34059833) Fasting plasma glucose ( 28270201) Gamma glutamyl transferase levels ( 33339817) Glycated hemoglobin levels ( 34059833 28898252) Hemoglobin A1c levels ( 29403010) Homeostasis model assessment of beta-cell function ( 20081858) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 22001757) Night sleep phenotypes ( 27126917) Response to metformin in type 2 diabetes (HbA1c reduction) ( 27500523) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Type 2 diabetes ( 30297969 32499647)
Interacting Genes		14 interacting genes: ATF3 CREB1 IAPP IFT88 MAFA NEUROD1 PBX1 PCIF1 PRKDC SLC2A2 SPOP TCF3 XRCC5 XRCC6	5 interacting genes: APP KPNA2 PDX1 PRKACA SUZ12
Entrez ID		3651	6514
HPRD ID		02843	00685
Ensembl ID		ENSG00000139515	ENSG00000163581
Uniprot IDs		P52945	P11168 Q6PAU8
PDB IDs		6F8F
Enriched GO Terms of Interacting Partners?
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