IL6ST and IL31RA

Number of citations of the paper that reports this interaction (PubMedID 15184896)
196

Data Source:
HPRD (in vivo)

		IL6ST	IL31RA
Description		interleukin 6 cytokine family signal transducer	interleukin 31 receptor A
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Interleukin-6 Receptor Complex Oncostatin-M Receptor Complex External Side Of Plasma Membrane Membrane Dendrite Neuronal Cell Body Receptor Complex Membrane Raft Extracellular Exosome Ciliary Neurotrophic Factor Receptor Complex	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Axon Presynaptic Membrane Receptor Complex
	Molecular Function	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Interleukin-6 Receptor Activity Interleukin-11 Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Protein Binding Growth Factor Binding Cytokine Binding Interleukin-11 Binding Interleukin-6 Binding Identical Protein Binding Interleukin-27 Receptor Activity Scaffold Protein Binding	Transcription Coactivator Activity Cytokine Receptor Activity Protein Kinase Binding Cytokine Binding Granulocyte Colony-stimulating Factor Binding
	Biological Process	Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Adaptive Immune Response Glycogen Metabolic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Cardiac Muscle Hypertrophy Cytokine-mediated Signaling Pathway Response To Cytokine Interleukin-11-mediated Signaling Pathway Oncostatin-M-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Astrocyte Differentiation Leukemia Inhibitory Factor Signaling Pathway Intestinal Epithelial Cell Development Interleukin-6-mediated Signaling Pathway Interleukin-27-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Platelet Aggregation	MAPK Cascade Glandular Epithelial Cell Differentiation Acute Inflammatory Response To Antigenic Stimulus Defense Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Monocyte Differentiation Macrophage Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Homeostatic Process Negative Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Defense Response To Other Organism
Pathways		Interleukin-6 signaling Interleukin-6 signaling IL-6-type cytokine receptor ligand interactions Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling	IL-6-type cytokine receptor ligand interactions
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Crohn's disease ( 23128233) IgG glycosylation ( 23382691) Mean spheric corpuscular volume ( 32888494) Rheumatoid arthritis ( 20453842) Type 1 diabetes ( 34127860)	Crohn's disease ( 23128233)
Interacting Genes		35 interacting genes: AR CDK9 CMYA5 CNTF CNTFR CTF1 ERBB2 ERBB3 FBXO2 HCK IL31RA IL6 IL6R JAK1 KCNIP1 KCNIP3 LIF LIFR MAGEA11 OSM OSMR PIK3CG PLAUR PRKCD PTPN11 PTPN6 SGTA SGTB SHC1 SOCS3 STAT3 TLE1 TYK2 UBQLN1 VAV1	2 interacting genes: IL6ST LIFR
Entrez ID		3572	133396
HPRD ID		02824	17145
Ensembl ID		ENSG00000134352	ENSG00000164509
Uniprot IDs		A0A0A0N0L2 P40189 Q17RA0	B4DNJ2 Q8NI17
PDB IDs		1BJ8 1BQU 1I1R 1N2Q 1P9M 1PVH 3L5H 3L5I 3L5J
Enriched GO Terms of Interacting Partners?
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