IL2RB and IL2

Number of citations of the paper that reports this interaction (PubMedID 8049354)
5

Data Source:
HPRD (in vivo)

		IL2RB	IL2
Description		interleukin 2 receptor subunit beta	interleukin 2
Image
GO Annotations	Cellular Component	Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Interleukin-2 Receptor Complex External Side Of Plasma Membrane Cell Surface Membrane	Extracellular Region Extracellular Space
	Molecular Function	Interleukin-2 Receptor Activity Protein Binding Interleukin-2 Binding Interleukin-15 Receptor Activity	Cytokine Activity Interleukin-2 Receptor Binding Protein Binding Growth Factor Activity Kinase Activator Activity Carbohydrate Binding Kappa-type Opioid Receptor Binding Glycosphingolipid Binding
	Biological Process	Signal Transduction Cytokine-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Phagocytosis Protein-containing Complex Assembly	Negative Regulation Of Protein Phosphorylation Adaptive Immune Response Leukocyte Activation Involved In Immune Response Positive Regulation Of Immunoglobulin Production Negative Regulation Of B Cell Apoptotic Process Immune Response Cell Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Gene Expression Natural Killer Cell Activation T Cell Differentiation Positive Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Kinase Activity Positive Regulation Of Tissue Remodeling Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Response To Ethanol Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Heart Contraction Positive Regulation Of Transcription By RNA Polymerase II Regulation Of T Cell Homeostatic Proliferation Positive Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of Dendritic Spine Development Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Plasma Cell Differentiation Negative Regulation Of T-helper 17 Cell Differentiation
Pathways		RAF/MAP kinase cascade Interleukin-15 signaling Interleukin-15 signaling Interleukin-2 signaling Interleukin receptor SHC signaling	RAF/MAP kinase cascade RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Interleukin-2 signaling Interleukin receptor SHC signaling
Drugs		Denileukin diftitox Aldesleukin Basiliximab Daclizumab	Pseudoephedrine Cefazolin SP4160 N(2)-carbamimidoyl-N-{2-[4-(3-{4-[(5-carboxyfuran-2-yl)methoxy]-2,3-dichlorophenyl}-1-methyl-1H-pyrazol-5-yl)piperidin-1-yl]-2-oxoethyl}-D-leucinamide 3-Mercapto-1-(1,3,4,9-Tetrahydro-B-Carbolin-2-Yl)-Propan-1-One Methyl (2S)-2-[[2-[(3R)-1-carbamimidoylpiperidin-3-yl]acetyl]amino]-3-[4-(2-phenylethynyl)phenyl]propanoate (1H-indol-3-yl)-(2-mercapto-ethoxyimino)-acetic acid SP2456 2-[2-(2-Cyclohexyl-2-guanidino-acetylamino)-acetylamino]-N-(3-mercapto-propyl)-propionamide keyhole limpet hemocyanin Girentuximab Tapinarof TG4010
Diseases
GWAS		Asthma ( 20860503 32296059) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) L-selectin levels ( 25576479) Lack of premeditation ( 30718321) Mean corpuscular volume ( 27863252) Rheumatoid arthritis ( 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Tuberculosis ( 24057671) Type 1 diabetes ( 21829393)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184) Allergic sensitization ( 30013184 23817571) Allergy ( 27182965) Alopecia areata ( 20596022 25608926) Asthma ( 31361310 31959851 30929738 31619474) Asthma (adult onset) ( 30929738) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 25574825 26482879 23727859) Bipolar disorder ( 31043756) Celiac disease ( 22057235 20190752 25920553 17558408 24999842 18311140) Crohn's disease ( 28067908) Eosinophil counts ( 32888494) IgE grass sensitization ( 22036096) Inflammatory bowel disease ( 28067908 23128233) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Medication use (adrenergics, inhalants) ( 31015401) Primary sclerosing cholangitis ( 23603763 27992413) Progressive supranuclear palsy ( 21685912) Rheumatoid arthritis ( 30423114 24390342 20453842) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 21829393 25751624 19430480) Ulcerative colitis ( 21297633) Vaso-occlusive pain in sickle-cell anemia ( 28584135)
Interacting Genes		32 interacting genes: CISH EIF3B FYN GRB2 HGS IL15 IL15RA IL2 IL2RA IL2RG JAK1 JAK3 LCK LYN MKKS MTDH ODF3B PIK3R1 PTPN6 RACK1 RAF1 SHB SHC1 SOCS1 SOCS3 SPIB STAT1 STAT3 STAT5A STAT5B SYK TRIP13	9 interacting genes: CD53 FGF2 FOXK2 IFNA1 IL2RA IL2RB IL2RG NGFR SHC1
Entrez ID		3560	3558
HPRD ID		00896	00979
Ensembl ID		ENSG00000100385	ENSG00000109471
Uniprot IDs		P14784	P60568 Q0GK43
PDB IDs		1ILM 1ILN 2B5I 2ERJ 3QAZ 4GS7 5M5E 6E8K	1ILM 1ILN 1IRL 1M47 1M48 1M49 1M4A 1M4B 1M4C 1NBP 1PW6 1PY2 1QVN 1Z92 2B5I 2ERJ 3INK 3QAZ 3QB1 4NEJ 4NEM 5LQB 5M5E 5UTZ 6LX3 6LXW 6VWU 6YE3
Enriched GO Terms of Interacting Partners?
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