IL2RA and ARHGAP12

		IL2RA	ARHGAP12
Description		interleukin 2 receptor subunit alpha	Rho GTPase activating protein 12
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Interleukin-2 Receptor Complex External Side Of Plasma Membrane	Phagocytic Cup Cytoplasm
	Molecular Function	Interleukin-2 Receptor Activity Protein Binding Interleukin-2 Binding	GTPase Activator Activity
	Biological Process	Inflammatory Response To Antigenic Stimulus Regulation Of T Cell Tolerance Induction Apoptotic Process Activation-induced Cell Death Of T Cells Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway Notch Signaling Pathway Interleukin-2-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Regulation Of T Cell Homeostatic Proliferation Negative Regulation Of Inflammatory Response	Morphogenesis Of An Epithelial Sheet Phagocytosis, Engulfment Actin Filament Organization Signal Transduction Regulation Of GTPase Activity Negative Regulation Of Small GTPase Mediated Signal Transduction
Pathways		RAF/MAP kinase cascade RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Interleukin-2 signaling Interleukin receptor SHC signaling	RAC1 GTPase cycle RHOD GTPase cycle RHOV GTPase cycle RHOF GTPase cycle
Drugs		Denileukin diftitox Aldesleukin Basiliximab Daclizumab
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Alopecia areata ( 20596022 25608926) Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 31361310 31959851 30929738 34103634 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (bronchodilator response) ( 23508266) Asthma (childhood onset) ( 30929738) Asthma and hay fever ( 24388013) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Autoimmune thyroid disease ( 32581359) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Autoimmune traits (pleiotropy) ( 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Diisocyanate-induced asthma ( 25918132) Eczema ( 31361310) Emotional dysregulation ( 27643478) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Epstein Barr virus nuclear antigen 1 IgG levels or multiple sclerosis ( 26819262) Graves' disease ( 22922229) Inflammatory biomarkers ( 22228203) Inflammatory bowel disease ( 23128233) Interleukin-2 receptor antagonist levels ( 27989323) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Liver fibrogenesis (alpha smooth muscle actin levels) ( 32953199) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Marginal zone lymphoma or multiple sclerosis ( 31407831) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244 22190364 24076602 19525953 19525955 17660530 21833088 27386562 28445677) Neutrophil percentage of white cells ( 32888494) Pediatric autoimmune diseases ( 26301688) Plasma t-tau levels ( 28100725) Primary sclerosing cholangitis ( 23603763 27992413) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Rheumatoid arthritis ( 24449572 30423114 30572963 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596) Selective IgA deficiency ( 27723758) Soluble interleukin-2 receptor subunit alpha ( 26293465) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 21829393 25751624 19430480 30572963 22293688 18978792) Vitiligo ( 20410501 27723757) White blood cell count ( 32888494)	C-reactive protein levels ( 24763700) Glycine levels ( 30837465) Intraocular pressure ( 31959993) Pulse pressure ( 28135244 27841878) Systolic blood pressure ( 27841878) Uterine fibroids ( 31649266)
Interacting Genes		17 interacting genes: AKR1C3 ARHGAP12 CALML3 CD4 FGF12 FKBP4 GTPBP4 ICAM1 IL2 IL2RB JCAD KIN NFKB1 PFKP SNTA1 STAT3 STAT5B	7 interacting genes: IL2RA RAC1 SHANK2 SRPK1 SRPK2 TRIP10 WASL
Entrez ID		3559	94134
HPRD ID		00986	06446
Ensembl ID		ENSG00000134460	ENSG00000165322
Uniprot IDs		P01589 Q5W005	Q1RLN5 Q8IWW6
PDB IDs		1ILM 1ILN 1Z92 2B5I 2ERJ 3IU3 3NFP 6VWU 6YIO
Enriched GO Terms of Interacting Partners?
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