LCE1F and IL34

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LCE1F	IL34
Description		late cornified envelope 1F	interleukin 34
Image		No pdb structure
GO Annotations	Cellular Component		Extracellular Region Extracellular Space
	Molecular Function	Protein Binding Identical Protein Binding	Cytokine Activity Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Keratinization	Positive Regulation Of Protein Phosphorylation Inflammatory Response Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Protein Tyrosine Kinase Activity Interleukin-34-mediated Signaling Pathway Microglial Cell Proliferation Positive Regulation Of Macrophage Proliferation
Pathways		Formation of the cornified envelope	Other interleukin signaling
Drugs
Diseases
GWAS		Asthma ( 31619474)	Alzheimer's disease ( 34099642) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Cerebrospinal P-tau181p levels ( 28247064) Diffuse cutaneous systemic sclerosis ( 29293537) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Intraocular pressure ( 29785010 30054594) Malaria ( 31844061)
Interacting Genes		74 interacting genes: ADAMTSL4 ALPP CATSPER1 CHIC2 CHRD CRCT1 CYP21A2 CYSRT1 FBLN1 HOXA1 IL34 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-10 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP2-3 KRTAP2-4 KRTAP3-2 KRTAP3-3 KRTAP4-11 KRTAP4-12 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE2B LCE2C LCE2D LCE3B LCE5A MACO1 MDFI NBPF19 NOTCH2NLA NTAQ1 OIT3 OTX1 PCSK5 POU4F2 PSMB1 RAD54L2 RGS20 RNF4 SLC39A7 SMCP SPRY1 SPRY2 SPRY3 TRIM42 UBE2I VWC2 WFDC3	3 interacting genes: ATXN1 LCE1F PTPRZ1
Entrez ID		353137	146433
HPRD ID		13970	14582
Ensembl ID		ENSG00000240386	ENSG00000157368
Uniprot IDs		Q5T754	A0A024QZ87 Q6ZMJ4
PDB IDs			4DKC 4DKD 4DKE 4DKF
Enriched GO Terms of Interacting Partners?
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