NIPAL4 and ACKR2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		NIPAL4	ACKR2
Description		NIPA like domain containing 4	atypical chemokine receptor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane Integral Component Of Membrane	Nucleoplasm Early Endosome Cytosol Actin Filament Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Nuclear Membrane Intracellular Membrane-bounded Organelle Recycling Endosome
	Molecular Function	Protein Binding Magnesium Ion Transmembrane Transporter Activity	Chemokine Receptor Activity Scavenger Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Magnesium Ion Transport Magnesium Ion Transmembrane Transport	Endocytosis Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Multicellular Organism Development Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Miscellaneous transport and binding events	Chemokine receptors bind chemokines
Drugs
Diseases
GWAS		Asthma ( 31959851)	Blood protein levels ( 29875488 28240269) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Eotaxin levels ( 27989323) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte chemoattractant protein-1 levels ( 27989323) Monocyte count ( 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Neutrophil count ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Thymus and reactivation regulated chemokine levels ( 33227023) White blood cell count ( 32888494 27863252)
Interacting Genes		15 interacting genes: ACKR2 CLDN7 CMTM2 COMT FFAR2 GJB1 GPR152 HHLA2 IL10RA LHFPL5 RNF185 RNF19B SSMEM1 TM4SF18 TRHR	27 interacting genes: APP CCL11 CCL13 CCL14 CCL19 CCL2 CCL21 CCL25 CCL27 CCL28 CCL3 CCL3L3 CCL4 CCL5 CCL7 CCL8 CREB3 DCP2 EFNA5 GJA8 GPX1 MS4A1 NIPAL4 RHOA SACM1L SLC13A4 TMEM167B
Entrez ID		348938	1238
HPRD ID		19424	09095
Ensembl ID		ENSG00000172548	ENSG00000144648
Uniprot IDs		Q0D2K0	A1LP82 O00590
PDB IDs
Enriched GO Terms of Interacting Partners?
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