IGF2R and CTSD

Number of citations of the paper that reports this interaction (PubMedID 15258139)
34

Data Source:
HPRD (in vivo)

		IGF2R	CTSD
Description		insulin like growth factor 2 receptor	cathepsin D
Image
GO Annotations	Cellular Component	Nuclear Envelope Lumen Endosome Early Endosome Late Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Endosome Membrane Membrane Clathrin Coat Transport Vesicle Endocytic Vesicle Trans-Golgi Network Transport Vesicle Secretory Granule Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Endosome Membrane Specific Granule Lumen Melanosome Lysosomal Lumen Membrane Raft Collagen-containing Extracellular Matrix Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	G-protein Alpha-subunit Binding Retinoic Acid Binding Insulin-like Growth Factor-activated Receptor Activity Protein Binding Insulin-like Growth Factor Binding Mannose Binding Enzyme Binding Insulin-like Growth Factor II Binding Signaling Receptor Activity Identical Protein Binding Phosphoprotein Binding Retromer Complex Binding	Aspartic-type Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Aspartic-type Peptidase Activity
	Biological Process	Liver Development Receptor-mediated Endocytosis Lysosomal Transport Signal Transduction G Protein-coupled Receptor Signaling Pathway Spermatogenesis Post-embryonic Development Animal Organ Regeneration Response To Retinoic Acid Positive Regulation Of Apoptotic Process Positive Regulation By Host Of Viral Process Insulin-like Growth Factor Receptor Signaling Pathway Response To Tetrachloromethane	Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Lipoprotein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Establishment Of Protein Localization
Pathways		Golgi Associated Vesicle Biogenesis Neutrophil degranulation Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Collagen degradation Metabolism of Angiotensinogen to Angiotensins MHC class II antigen presentation Neutrophil degranulation Estrogen-dependent gene expression
Drugs		Mecasermin alpha-D-mannose 6-phosphate Cerliponase alfa Mecasermin rinfabate	Insulin pork S-Methylcysteine 1h-Benoximidazole-2-Carboxylic Acid 2-Morpholinoethylamine 5-AMINO-6-CYCLOHEXYL-4-HYDROXY-2-ISOBUTYL-HEXANOIC ACID CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Blood protein levels ( 30072576 29875488 28240269) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Brain lesion load ( 19010793) Coronary artery disease ( 29212778) LDL cholesterol levels ( 32203549) Lipoprotein (a) levels ( 26377243) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Periodontitis (CDC/AAP) ( 24024966) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 33031748)	Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Logical memory (delayed recall) in mild cognitive impairment ( 29274321)
Interacting Genes		14 interacting genes: AGA ATXN1 CREG1 CSNK2A1 CTSD GGA1 GGA2 GGA3 GZMB IGF2 PACS1 PLAU PLAUR PLIN3	25 interacting genes: APP BGLAP CCL21 CD4 CST3 CSTB CTSB FN1 HSPB2 IGF2R IGFBP3 IGFBP4 INS MAPK1 MAPT NEAT1 NLGN3 OGT PSAP SERPINA4 SHBG SLC2A4 SNCA SPRED2 TG
Entrez ID		3482	1509
HPRD ID		00928	00291
Ensembl ID		ENSG00000197081	ENSG00000117984
Uniprot IDs		P11717	P07339 V9HWI3
PDB IDs		1E6F 1GP0 1GP3 1GQB 1JPL 1JWG 1LF8 2CNJ 2L29 2L2A 2M68 2M6T 2V5N 2V5O 2V5P 5IEI 6N5X 6N5Y 6P8I 6V02 6Z30 6Z31 6Z32	1LYA 1LYB 1LYW 4OBZ 4OC6 4OD9
Enriched GO Terms of Interacting Partners?
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