IFNG and PDIA3

Number of citations of the paper that reports this interaction (PubMedID 8974399)
96

Data Source:
HPRD (in vivo)

		IFNG	PDIA3
Description		interferon gamma	protein disulfide isomerase family A member 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Space Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Focal Adhesion Cell Surface Melanosome MHC Class I Peptide Loading Complex Phagocytic Vesicle Recycling Endosome Membrane Extracellular Exosome
	Molecular Function	Cytokine Activity Interferon-gamma Receptor Binding Protein Binding	RNA Binding Protein Disulfide Isomerase Activity Cysteine-type Endopeptidase Activity Phospholipase C Activity Protein Binding Protein-disulfide Reductase Activity Disulfide Oxidoreductase Activity Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Microglial Cell Activation Positive Regulation Of Cytokine Production Positive Regulation Of Protein Phosphorylation Adaptive Immune Response Macrophage Activation Involved In Immune Response Apoptotic Process Humoral Immune Response Cell Surface Receptor Signaling Pathway Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Response To Virus Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Regulation Of Protein ADP-ribosylation Macrophage Differentiation Negative Regulation Of Epithelial Cell Differentiation Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Interleukin-17 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Involved In Immune Response Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Positive Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Growth Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Glycolytic Process Negative Regulation Of Transcription, DNA-templated Astrocyte Activation Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Positive Regulation Of Neurogenesis Regulation Of Insulin Secretion Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Nitrogen Compound Metabolic Process Defense Response To Virus Positive Regulation Of Killing Of Cells Of Other Organism Regulation Of Cell Cycle Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Fructose 1,6-bisphosphate 1-phosphatase Activity Positive Regulation Of Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Deacetylation Extrinsic Apoptotic Signaling Pathway Neuroinflammatory Response Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Neuron Death Positive Regulation Of Cellular Respiration Positive Regulation Of Amyloid-beta Formation Negative Regulation Of Tau-protein Kinase Activity Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Exosomal Secretion Positive Regulation Of Iron Ion Import Across Plasma Membrane Positive Regulation Of NMDA Glutamate Receptor Activity Positive Regulation Of Core Promoter Binding Positive Regulation Of Signaling Receptor Activity Positive Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production	Protein Folding Proteolysis Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Cellular Response To Interleukin-7 Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	ER-Phagosome pathway ER-Phagosome pathway Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs		Olsalazine Glucosamine VIR201 Fontolizumab Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Emapalumab	Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Alopecia areata ( 25608926) Anti-saccade response ( 29064472) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Systemic lupus erythematosus ( 28714469) Ulcerative colitis ( 20228799 21297633 19122664)	Blood protein levels ( 30072576) Lead levels ( 26025379) Liver volume ( 34128465) Triglyceride levels ( 32203549)
Interacting Genes		6 interacting genes: CDK4 IFNGR1 IFNGR2 PDIA3 STAT6 TNF	25 interacting genes: APP BACE1 CACNB2 CALR CANX ERO1A ERP27 ESR1 FBLN5 GYPC HLA-A IFNG LINC01554 MDM2 MTNR1B OGT PCAT1 PLCB2 SEC11A SLC12A3 SLC2A1 STAT3 SUMO4 TAP1 UBE3A
Entrez ID		3458	2923
HPRD ID		00957	03625
Ensembl ID		ENSG00000111537	ENSG00000167004
Uniprot IDs		P01579	P30101 V9HVY3
PDB IDs		1EKU 1FG9 1FYH 1HIG 3BES 6E3K 6E3L	2ALB 2DMM 2H8L 3F8U 6ENY
Enriched GO Terms of Interacting Partners?
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