NANOS1 and GRIN2D

Number of citations of the paper that reports this interaction (PubMedID 10862698)
367

Data Source:
HPRD (in vivo)

		NANOS1	GRIN2D
Description		nanos C2HC-type zinc finger 1	glutamate ionotropic receptor NMDA type subunit 2D
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane NMDA Selective Glutamate Receptor Complex Postsynaptic Density Membrane
	Molecular Function	MRNA Binding Protein Binding Zinc Ion Binding Translation Repressor Activity	Ionotropic Glutamate Receptor Activity NMDA Glutamate Receptor Activity Protein Binding Ligand-gated Ion Channel Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity
	Biological Process	Regulation Of Cell Growth Tissue Homeostasis Posttranscriptional Regulation Of Gene Expression Epithelial Cell Migration Cell Migration Negative Regulation Of Translation Oogenesis Cerebellar Neuron Development Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay	Startle Response Brain Development Adult Locomotory Behavior Calcium-mediated Signaling Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Synaptic Plasticity Regulation Of Sensory Perception Of Pain Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Import Into Cytosol Excitatory Chemical Synaptic Transmission
Pathways			Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs			Glutamic acid Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Acamprosate Donepezil Guaifenesin Memantine Orphenadrine Phenobarbital Aripiprazole Tenocyclidine Prasterone Milnacipran Acetylcysteine Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Keratoconus ( 33649486) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		3 interacting genes: GRIN1 GRIN2D PUM2	33 interacting genes: ABL1 CDH2 CIT CLTC CTNNB1 DLG2 DLG4 DLGAP4 DNM1 DUSP4 FUS GRIN1 HNRNPU HRAS HSPA1A IL16 INA MAP2 MAP2K2 NANOS1 NF1 PATJ PPP2R1A PPP2R2A PRKCB PRKCE PRKCG RAP2A RPS6KA3 SPTAN1 SYNGAP1 TJP1 TRAF3
Entrez ID		340719	2906
HPRD ID		16302	04095
Ensembl ID		ENSG00000188613	ENSG00000105464
Uniprot IDs		Q8WY41	O15399 Q59G17
PDB IDs		4CQO
Enriched GO Terms of Interacting Partners?
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