VWA2 and PTPN3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		VWA2	PTPN3
Description		von Willebrand factor A domain containing 2	protein tyrosine phosphatase non-receptor type 3
Image		No pdb structure
GO Annotations	Cellular Component	Basement Membrane Extracellular Space Collagen-containing Extracellular Matrix Extracellular Exosome	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Identical Protein Binding	Phosphotyrosine Residue Binding Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Sodium Channel Regulator Activity ATPase Binding
	Biological Process	Calcium-independent Cell-matrix Adhesion Regulation Of Insulin Receptor Signaling Pathway	MAPK Cascade Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Membrane Protein Ectodomain Proteolysis Liver Regeneration Regulation Of Membrane Depolarization During Action Potential Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways			EGFR downregulation Negative regulation of MAPK pathway
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Lymphocyte counts ( 32888494) Monocyte count ( 32888494)	Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) HIV-associated neurocognitive disorder ( 28447399) HIV-associated neurocognitive disorder (asymptomatic neurocogntive impairment) ( 28447399) HIV-associated neurocognitive disorder (mild neurocognitive disorder or asymptomatic neurocognitive impairment) ( 28447399) Iris color (a* coordinate) ( 30895295) Iris color (b* coordinate) ( 30895295) Red blood cell density in sickle cell anemia ( 28552477) Serum albumin level ( 29403010) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Triglyceride levels ( 32203549)
Interacting Genes		2 interacting genes: PTPN3 TRAF2	27 interacting genes: ACE2 ADAM17 AKR1C1 AKT1 CD247 DIP2A GHR HSPB1 LMO1 MAPK12 MLH1 MTMR9 NXT2 PLEKHF2 RNF111 RPS6KA1 TENT5D TFAP4 TRIM41 VCP VWA2 WDR6 YWHAB YWHAG YWHAQ ZAP70 ZCCHC10
Entrez ID		340706	5774
HPRD ID		16481	06767
Ensembl ID		ENSG00000165816	ENSG00000070159
Uniprot IDs		Q5GFL6	B7Z3V3 B7Z9V1 B7ZA03 P26045 Q8N4S3
PDB IDs			2B49 4QUM 4QUN 4RH5 4RH9 4RHG 4RI4 4RI5 4S0G 6HKS 6T36
Enriched GO Terms of Interacting Partners?
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