ENPP7 and CIT

		ENPP7	CIT
Description		ectonucleotide pyrophosphatase/phosphodiesterase 7	citron rho-interacting serine/threonine kinase
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Microvillus Membrane	Cytoplasm Cytosol Cytoskeleton Membrane
	Molecular Function	Sphingomyelin Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Zinc Ion Binding	Transcription Coactivator Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding SH3 Domain Binding Protein Kinase Binding PDZ Domain Binding Protein Serine/threonine Kinase Inhibitor Activity Metal Ion Binding Scaffold Protein Binding Protein Serine Kinase Activity
	Biological Process	Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Glycosphingolipid Metabolic Process Negative Regulation Of DNA Replication Negative Regulation Of Cell Population Proliferation Lipid Digestion Positive Regulation Of Intestinal Cholesterol Absorption Fatty Acid Homeostasis Regulation Of Intestinal Lipid Absorption Positive Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Sphingomyelin Catabolic Process	Mitotic Cell Cycle Mitotic Cytokinesis Peptidyl-threonine Phosphorylation Actomyosin Structure Organization Positive Regulation Of Cytokinesis Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Negative Regulation Of Catalytic Activity Generation Of Neurons Neuron Apoptotic Process
Pathways		Glycosphingolipid metabolism	RHO GTPases activate CIT RHO GTPases activate CIT RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415)	Mitochondrial heteroplasmy measurement ( 33731350) Number of sexual partners ( 30643258) Urgency urinary incontinence ( 25524241)
Interacting Genes		7 interacting genes: BACH2 CIT GOLGA2 KRTAP5-9 LRRC73 MTUS2 SRC	16 interacting genes: ABCB9 DERA DISC1 DLG4 ENPP7 GRIN1 GRIN2D HIP1R MLXIPL MTNR1A RAC1 RHOA RHOB RHOC RND3 SELPLG
Entrez ID		339221	11113
HPRD ID		10938	09289
Ensembl ID		ENSG00000182156	ENSG00000122966
Uniprot IDs		Q6UWV6	O14578
PDB IDs		5TCD 5UDY
Enriched GO Terms of Interacting Partners?
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