RAB7B and RAP1B

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		RAB7B	RAP1B
Description		RAB7B, member RAS oncogene family	RAP1B, member of RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Late Endosome Golgi Apparatus Trans-Golgi Network Phagocytic Vesicle Membrane Late Endosome Membrane Phagocytic Vesicle	Lipid Droplet Cytosol Plasma Membrane Cell-cell Junction Membrane Azurophil Granule Membrane Membrane Raft Extracellular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding	GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding Protein-containing Complex Binding
	Biological Process	Endosome To Lysosome Transport Protein Transport Positive Regulation Of Interleukin-6 Production Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Late Endosome To Golgi Transport Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Interferon-gamma Phagosome-lysosome Fusion	Cell Population Proliferation Response To Carbohydrate Microvillus Assembly Rap Protein Signal Transduction Positive Regulation Of Integrin Activation Negative Regulation Of Calcium Ion-dependent Exocytosis Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Cellular Response To Xenobiotic Stimulus Cellular Response To Gonadotropin-releasing Hormone Regulation Of Cell Junction Assembly Regulation Of Establishment Of Cell Polarity Negative Regulation Of Synaptic Vesicle Exocytosis
Pathways		TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs
Diseases
GWAS			Femoral neck bone mineral density ( 32239398) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) HDL cholesterol levels in HIV infection ( 33109212) White blood cell count ( 20139978)
Interacting Genes		3 interacting genes: APP APPBP2 RAP1B	30 interacting genes: A2M ALAS1 APLP1 APP CCT7 CHGB CSAD DDAH2 FAF1 HRAS KMT2B LRIF1 MTUS2 PDHB PKM PRKACA RAB7B RALGDS RAPGEF1 RASSF5 RGL2 RGS2 RPTOR SDF4 SMURF2 TLE1 TP53 UNC119 ZDHHC17 ZNF135
Entrez ID		338382	5908
HPRD ID		15202	01546
Ensembl ID		ENSG00000276600	ENSG00000127314
Uniprot IDs		A0A096LP44 Q96AH8	A0A024RB87 B7ZAY2 P61224
PDB IDs			3BRW 3CF6 4DXA 4HDO 4HDQ 4M8N 4MGI 4MGK 4MGY 4MGZ 4MH0 5KHO 6AXF 6BA6 6KYK 6OQ3 6OQ4 6UZK
Enriched GO Terms of Interacting Partners?
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