ICAM1 and SLC3A2

Number of citations of the paper that reports this interaction (PubMedID 12716892)
11

Data Source:
HPRD (in vivo)

		ICAM1	SLC3A2
Description		intercellular adhesion molecule 1	solute carrier family 3 member 2
Image
GO Annotations	Cellular Component	Immunological Synapse Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Membrane Raft Collagen-containing Extracellular Matrix Extracellular Exosome	Nucleoplasm Lysosomal Membrane Plasma Membrane Basal Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Melanosome Apical Pole Of Neuron Synapse Extracellular Exosome Amino Acid Transport Complex
	Molecular Function	Virus Receptor Activity Transmembrane Signaling Receptor Activity Integrin Binding Protein Binding Signaling Receptor Activity	RNA Binding Double-stranded RNA Binding Catalytic Activity Calcium:sodium Antiporter Activity Protein Binding Aromatic Amino Acid Transmembrane Transporter Activity Neutral Amino Acid Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity L-leucine Transmembrane Transporter Activity Cadherin Binding
	Biological Process	Ovarian Follicle Development Regulation Of Leukocyte Mediated Cytotoxicity Response To Amphetamine T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Acute Inflammatory Response To Antigenic Stimulus T Cell Antigen Processing And Presentation Positive Regulation Of Cellular Extravasation Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell Aging Sensory Perception Of Sound Regulation Of Cell Shape Response To Xenobiotic Stimulus Response To Ionizing Radiation Response To Sulfur Dioxide Membrane To Membrane Docking Positive Regulation Of Actin Filament Polymerization Cellular Response To Nutrient Levels Response To Insulin Cell Adhesion Mediated By Integrin Response To Gonadotropin Response To Amino Acid Positive Regulation Of GTPase Activity Adhesion Of Symbiont To Host Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Ethanol Positive Regulation Of Vasoconstriction Response To Copper Ion Viral Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Calcium Ion Transport Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Alkaloid Cellular Response To Glucose Stimulus Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus T Cell Extravasation Establishment Of Endothelial Intestinal Barrier Establishment Of Sertoli Cell Barrier Regulation Of Ruffle Assembly Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cellular Response To Amyloid-beta Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Endothelial Cell Apoptotic Process	Carbohydrate Metabolic Process Calcium Ion Transport Amino Acid Transport Leucine Transport Phenylalanine Transport Tryptophan Transport Sodium Ion Transmembrane Transport Response To Exogenous DsRNA Viral Entry Into Host Cell Leucine Import Across Plasma Membrane L-leucine Import Across Plasma Membrane L-alanine Import Across Plasma Membrane
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling	Basigin interactions Amino acid transport across the plasma membrane Defective SLC7A7 causes lysinuric protein intolerance (LPI) Tryptophan catabolism
Drugs		Natalizumab Hyaluronic acid Nafamostat
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Crohn's disease ( 21102463) Height ( 31562340) Inflammatory bowel disease ( 23128233) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low white blood cell count (conditioned on rs2814778) ( 29596498) Lymphocyte counts ( 32888494 27863252) Monocyte count ( 32888494) Pulse pressure ( 27841878) Soluble ICAM-1 ( 21533024 31217265 18604267) White blood cell count ( 32888494)	Iron status biomarkers (transferrin saturation) ( 28334935) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		28 interacting genes: BCL7B BRAF CALR CYSRT1 EGFR EZR FANCF FGG HDAC1 HSD3B7 IL2RA IL2RG ITGAL ITGAM ITGB2 KEAP1 KIF1A KRTAP10-8 MAP2K7 MC1R MSN MTPN MYO1F SLC3A2 SLCO2B1 SPN TBL3 UBQLN2	17 interacting genes: CCR4 EBP EGFR GPR37 HNRNPD ICAM1 ITGB1 MTNR1B NPSR1 RELA SLC7A10 SLC7A11 SLC7A5 SLC7A7 SLC7A8 TLCD3A VHL
Entrez ID		3383	6520
HPRD ID		00996	01148
Ensembl ID		ENSG00000090339	ENSG00000168003
Uniprot IDs		A0A384MEK5 P05362	J3KPF3 P08195
PDB IDs		1D3E 1D3I 1D3L 1IAM 1IC1 1IJ4 1MQ8 1P53 1Z7Z 2OZ4 3TCX 5MZA 6EIT 6S8U	2DH2 2DH3 6IRS 6IRT 6JMQ 6JMR 6S8V 7CCS 7CMH 7CMI
Enriched GO Terms of Interacting Partners?
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