KRTAP19-1 and HHEX

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		KRTAP19-1	HHEX
Description		keratin associated protein 19-1	hematopoietically expressed homeobox
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament	Chromatin Nucleus Cytoplasm Protein-DNA Complex
	Molecular Function	Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Transcription Factor Binding Eukaryotic Initiation Factor 4E Binding DNA Binding, Bending TBP-class Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding DNA-binding Transcription Factor Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II MRNA Export From Nucleus Response To Wounding Anterior/posterior Pattern Specification Negative Regulation Of Transcription By Transcription Factor Localization Negative Regulation Of Transcription By Competitive Promoter Binding Wnt Signaling Pathway Negative Regulation Of Angiogenesis Poly(A)+ MRNA Export From Nucleus Cell Differentiation Positive Regulation Of Wnt Signaling Pathway B Cell Differentiation Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Localization To Nucleus Response To Peptide Hormone Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Leukocyte Proliferation DNA Conformation Change Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Keratinization
Drugs
Diseases
GWAS			Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Asthma ( 31619474) Birth weight ( 31043758 27680694) Body mass index ( 28892062) Circulating leptin levels or type 2 diabetes ( 32341051) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Dehydroepiandrosterone sulphate levels ( 21533175) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Hemoglobin A1c levels ( 29403010) Inflammatory bowel disease ( 28067908) Insulin disposition index ( 24699409) Insulin levels in response to oral glucose tolerance test (30 minutes) ( 29093273) Intraocular pressure ( 29785010) Multiple sclerosis ( 31604244 24076602 21833088) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Type 2 diabetes ( 22885922 18372903 24509480 17293876 30054458 22693455 20862305 29358691 30297969 26818947 23945395 32499647 20581827 19401414 17463246 30718926 17463248 17463249 28869590)
Interacting Genes		46 interacting genes: ATG9A BAHD1 BCL6 BHLHE40 C11orf87 CCDC120 CCDC24 CERK CYSRT1 DAZAP2 DTX2 ENKD1 FAM168A FOXI1 HEMK1 HHEX INCA1 INO80B KPRP KRTAP15-1 MGAT5B PATZ1 PEF1 PLAC8 PLSCR4 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB1 PSMB2 RBPMS RHBG RNF44 RUSC1 SNRPB TEKT4 TLX3 VENTX VGLL3 ZC3H10 ZIC1 ZNF414 ZNF503	40 interacting genes: ABI1 ABI2 APOBEC3C CYSRT1 EFEMP2 GATA2 GATA6 JUN KHDRBS2 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP19-1 KRTAP2-3 KRTAP2-4 KRTAP4-12 KRTAP5-7 KRTAP5-8 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 MDFI NBPF19 NOTCH2NLA PFDN5 PML PSMA3 PSTPIP1 RBMY1F RBMY1J SOX10 SOX8 TLE1 TLE5 TP53BP2 TRMT6
Entrez ID		337882	3087
HPRD ID		11205	06829
Ensembl ID		ENSG00000184351	ENSG00000152804
Uniprot IDs		Q8IUB9	Q03014
PDB IDs			2E1O
Enriched GO Terms of Interacting Partners?
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