IAPP and PCSK1

Number of citations of the paper that reports this interaction (PubMedID 3053705)
46

Data Source:
HPRD (in vitro, in vivo)

		IAPP	PCSK1
Description		islet amyloid polypeptide	proprotein convertase subtilisin/kexin type 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Space Membrane Transport Vesicle Secretory Granule Lumen Neuron Projection
	Molecular Function	Amyloid-beta Binding Signaling Receptor Binding Hormone Activity Protein Binding Identical Protein Binding	Serine-type Endopeptidase Activity Identical Protein Binding
	Biological Process	Apoptotic Process Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Positive Regulation Of Protein Kinase A Signaling Negative Regulation Of Mitochondrion Organization Sensory Perception Of Pain Negative Regulation Of Protein-containing Complex Assembly Eating Behavior Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Cell Differentiation Negative Regulation Of Bone Resorption Positive Regulation Of Protein Kinase B Signaling Amylin Receptor Signaling Pathway Negative Regulation Of Amyloid Fibril Formation	Proteolysis Cell-cell Signaling Protein Processing Peptide Hormone Processing Peptide Biosynthetic Process
Pathways		Regulation of gene expression in beta cells G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production Amyloid fiber formation	Peptide hormone biosynthesis Insulin processing Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin
Drugs		Copper	Insulin pork
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132)	Adult body size ( 32376654) Blood protein levels ( 30072576 29875488) BMI at adiposity peak ( 31840077) Body mass index ( 22344219 24861553 28892062 25673413 29273807) Body mass index and fasting glucose (pairwise) ( 33619380) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood glucose adjusted for BMI ( 25625282) Fasting blood proinsulin levels ( 23263489) Fasting glucose ( 33402679 34059833) Glycemic traits (pregnancy) ( 23903356) Insulin-related traits (multivariate analysis) ( 32002517) Menarche (age at onset) ( 25231870) Proinsulin levels ( 21873549) Type 2 diabetes ( 32499647) Waist circumference ( 23966867)
Interacting Genes		6 interacting genes: COL25A1 PCSK1 PCSK2 PDX1 RAMP1 RAMP2	5 interacting genes: FER IAPP PCSK1N PMCH REN
Entrez ID		3375	5122
HPRD ID		01005	01201
Ensembl ID		ENSG00000121351	ENSG00000175426
Uniprot IDs		A0A024RAU1 P10997	P29120
PDB IDs		1KUW 2G48 2KB8 2L86 3DG1 3FPO 3FR1 3FTH 3FTK 3FTL 3FTR 3G7V 3G7W 3HGZ 5K5G 5KNZ 5KO0 5MGQ 6UCJ 6UCK 6VW2 6Y1A 6ZRF 6ZRQ 6ZRR
Enriched GO Terms of Interacting Partners?
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