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HTR2C and CNIH1
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
86
Data Source:
BioGRID
(two hybrid)
HTR2C
CNIH1
Description
5-hydroxytryptamine receptor 2C
cornichon family AMPA receptor auxiliary protein 1
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Dendrite
Synapse
G Protein-coupled Serotonin Receptor Complex
Golgi Membrane
Endoplasmic Reticulum Membrane
ER To Golgi Transport Vesicle Membrane
Integral Component Of Membrane
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Molecular Function
Gq/11-coupled Serotonin Receptor Activity
G Protein-coupled Serotonin Receptor Activity
Protein Binding
Neurotransmitter Receptor Activity
Identical Protein Binding
Serotonin Binding
1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding
Protein Binding
Biological Process
Behavioral Fear Response
Cellular Calcium Ion Homeostasis
G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Phospholipase C-activating Serotonin Receptor Signaling Pathway
Chemical Synaptic Transmission
Locomotory Behavior
Feeding Behavior
Response To Xenobiotic Stimulus
Positive Regulation Of Phosphatidylinositol Biosynthetic Process
CGMP-mediated Signaling
Regulation Of Nervous System Process
Regulation Of Appetite
Regulation Of Corticotropin-releasing Hormone Secretion
Positive Regulation Of Fat Cell Differentiation
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
G Protein-coupled Serotonin Receptor Signaling Pathway
Immune Response
Signal Transduction
Vesicle-mediated Transport
Pathways
Serotonin receptors
G alpha (q) signalling events
COPII-mediated vesicle transport
Cargo concentration in the ER
Drugs
Tramadol
Ziprasidone
Methysergide
Cabergoline
Amitriptyline
Olanzapine
Clozapine
Mirtazapine
Loxapine
Promazine
Cyproheptadine
Imipramine
Fluoxetine
Chlorpromazine
Chlorpromazine
Haloperidol
Nortriptyline
Amoxapine
Fenfluramine
Lisuride
Fluphenazine
Trazodone
Ergotamine
Apomorphine
Paroxetine
Trimipramine
Risperidone
Propiomazine
Minaprine
Cyclobenzaprine
Maprotiline
Ergoloid mesylate
Tegaserod
Doxepin
Nefazodone
Desipramine
Escitalopram
Pergolide
Dexfenfluramine
Bromocriptine
Ketamine
Quetiapine
Aripiprazole
Chlorprothixene
Clomipramine
Paliperidone
Yohimbine
Methotrimeprazine
Midomafetamine
4-Bromo-2,5-dimethoxyphenethylamine
Lorcaserin
Dapoxetine
Lofexidine
Epicept NP-1
Sertindole
Mianserin
Pizotifen
Asenapine
Ocaperidone
Dotarizine
Deramciclane
Agomelatine
Esmirtazapine
Captodiame
Etoperidone
Lorpiprazole
Setiptiline
Dihydroergocornine
m-Chlorophenylpiperazine
Gilteritinib
Sarpogrelate
Eplivanserin
Tiapride
Dihydroergocristine
2,5-Dimethoxy-4-ethylthioamphetamine
Aripiprazole lauroxil
Diseases
GWAS
Monobrow thickness (
26926045
)
Interacting Genes
34 interacting genes:
APBA1
ARRB2
ATP2B3
ATP6AP2
ATP6V0C
C4orf3
CALM1
CBX3
CNIH1
CRELD1
DLG4
EMP1
ERG28
GHITM
GJA1
GNAQ
GPR37
GPRC5B
LIN7C
MFSD14A
MPDZ
PLP1
RTN4
SGCB
SLC29A1
SLC39A1
SLC39A9
SNTA1
SPNS1
TM9SF2
TMBIM6
TMEM147
TMEM94
TPI1
30 interacting genes:
AQP6
BIK
CD53
CD79A
CLDN7
CPLX4
CYB5R3
ERGIC3
EVI2B
FAM209A
FCER1G
FFAR2
GPR152
GPX8
HTR2C
LEUTX
LRRC59
MCEMP1
MFF
MRM1
OPRM1
RNF24
SHISA4
SLC10A6
SLC18A1
SLC22A23
SLC35C2
SMIM3
TMEM52B
TSC1
Entrez ID
3358
10175
HPRD ID
02429
16730
Ensembl ID
ENSG00000147246
ENSG00000100528
Uniprot IDs
K9J958
P28335
B2R4P1
O95406
PDB IDs
6BQG
6BQH
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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