HOXA1 and DOCK3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		HOXA1	DOCK3
Description		homeobox A1	dedicator of cytokinesis 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Sensory Perception Of Sound Optokinetic Behavior Anatomical Structure Morphogenesis Abducens Nerve Formation Outer Ear Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Embryonic Neurocranium Morphogenesis Inner Ear Development Artery Morphogenesis Regulation Of Behavior Cognition Neuromuscular Process Artery Development Semicircular Canal Formation Cochlea Development Cochlea Morphogenesis	Small GTPase Mediated Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle NTRK2 activates RAC1 NTRK2 activates RAC1 Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Chronic venous disease ( 28374850) Macular thickness ( 30535121) Multiple sclerosis ( 31604244) Small cell lung carcinoma ( 28604730) Tonsillectomy ( 27182965 28928442)	Age at first birth ( 34211149) Asthma ( 32296059) Bacteremia ( 27236921) Blood protein levels ( 28240269) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat mass ( 28552196) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from coffee or tea ( 33287642) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cocaine dependence ( 31212010) Colorectal cancer ( 29228715) Cortical surface area (MOSTest) ( 32665545) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Estimated glomerular filtration rate ( 31152163) Height ( 20881960 25282103) Hip circumference adjusted for BMI ( 34021172) Melanoma ( 24980573) Morning person ( 30696823) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Trunk fat mass ( 28552196) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		339 interacting genes: ACOT7 ADAM12 ADAMTSL2 ADAMTSL4 AGAP3 AGRN AGXT ALG13 ALPP AMMECR1 AMOT ANKS1A ARID5A ARMC7 ATG9B ATP23 ATXN2L BAG4 BAHD1 BATF2 BEND5 BHLHB9 BLCAP BLZF1 BSCL2 BSDC1 BUD31 C11orf1 C11orf16 CATSPER1 CCDC120 CCDC33 CCN3 CCN4 CCN5 CCNK CD163 CD164 CDPF1 CERCAM CFP CHIC2 CHRD CHRDL2 CIR1 CNFN CNNM3 COL8A1 CREB5 CRELD1 CRELD2 CUTA CXCL16 CYHR1 CYP21A2 CYSRT1 DBF4B DCTN1 DKK3 DOCK2 DOCK3 DOK3 DTX2 DUSP10 DUSP22 EEF1A1 EFEMP1 EFEMP2 EGFL7 ENKD1 EPDR1 ESM1 ESR2 EVA1B FAAP100 FAM219B FAM221A FBLN1 FBLN2 FBLN5 FBN1 FHL3 FHL5 FN1 FOXH1 FOXN1 FRS3 FST FUCA2 GAS8 GATA1 GCM2 GDF15 GNE GP9 GPS2 GRN GSTP1 GUCD1 HEXB HEXIM2 HEY2 HOXB9 HR HSD3B7 ID3 IGFL1 IGFN1 INCA1 INO80B IRX6 ITGB4 ITGB8 JAG2 KCTD9 KDM1A KPRP KRT31 KRT33B KRT34 KRT35 KRT37 KRT38 KRT40 KRT81 KRT82 KRT83 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-4 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-2 KRTAP13-3 KRTAP13-4 KRTAP15-1 KRTAP19-6 KRTAP19-7 KRTAP2-3 KRTAP2-4 KRTAP23-1 KRTAP26-1 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LAMA5 LAMB2 LASP1 LCE1A LCE1B LCE1C LCE1D LCE1F LCE2A LCE2B LCE2C LCE2D LCE3C LCE3E LCE4A LCE5A LGALS13 LGALS4 LIMS2 LMX1B LNX1 LONRF1 LPXN LTBP1 LTBP3 LTBP4 LUC7L2 MACO1 MAPKBP1 MDFI MEGF6 MEGF8 MFAP2 MGAT5B MKRN3 MLLT11 MYO15B MYPOP N4BP2L2 NBPF19 NCK2 NECTIN2 NEDD9 NEK6 NELL1 NELL2 NFKBID NOTCH1 NOTCH2NLA NOTCH3 NR1D2 NTN4 NUCB1 NXF1 ODF1 OIT3 OPLAH P2RY6 PAX6 PBX2 PCSK5 PCYOX1 PCYT2 PHETA1 PIK3R1 PIN1 PITX1 PITX2 PKM PKNOX1 PLEKHN1 PLLP PLSCR1 PLSCR2 PLSCR3 PLSCR4 PPP1R32 PRICKLE4 PRMT6 PROP1 PSMB1 PTH1R PVR PYCR3 QARS1 R3HDM1 RALGDS RANBP3 RBCK1 RBP3 RBPMS RCHY1 RGS17 RGS19 RGS20 RNF208 RSPO2 RTN4R SCT SDCBP SIVA1 SLC15A3 SLC23A1 SLIT1 SLIT2 SLPI SND1 SNRPB SNRPC SPATA12 SPATA18 SPRY1 SPRY2 SPRY3 SPRY4 SSC4D SSUH2 STX11 SUV39H1 TBC1D10C TBR1 TBX15 TCF19 TCF3 TEKT4 TEKT5 TGFB1 TGFB1I1 TGM7 THAP7 TLE5 TNS2 TRAF1 TRAF2 TRAF4 TRAPPC6A TRIM42 TRIM55 TRIM63 TRIM8 TRIP6 TSPAN4 UBL5 UNKL VASN VWC2 VWC2L VWCE VWF WDR83 WWOX YIPF3 YPEL3 ZBTB16 ZIM2 ZMAT1 ZNF417 ZNF587 ZNF688 ZNF774 ZNF837 ZNF843 ZNRF3	10 interacting genes: CALM1 CRK HOXA1 KHDRBS1 NR3C1 PLEKHF2 PSEN1 PSEN2 RAC1 SRPK2
Entrez ID		3198	1795
HPRD ID		00843	10341
Ensembl ID		ENSG00000105991	ENSG00000088538
Uniprot IDs		P49639	Q8IZD9
PDB IDs
Enriched GO Terms of Interacting Partners?
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