HMOX2 and VMA21

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		HMOX2	VMA21
Description		heme oxygenase 2	vacuolar ATPase assembly factor VMA21
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Membrane Specific Granule Membrane	Lysosome Endoplasmic Reticulum Membrane ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Heme Oxygenase (decyclizing) Activity Protein Binding Heme Binding Metal Ion Binding	Protein Binding
	Biological Process	Response To Hypoxia Heme Oxidation Response To Oxidative Stress Heme Catabolic Process Iron Ion Homeostasis	Regulation Of ATPase Activity Vacuolar Proton-transporting V-type ATPase Complex Assembly
Pathways		Heme degradation Neutrophil degranulation RHOA GTPase cycle Iron uptake and transport Cytoprotection by HMOX1
Drugs		NADH Stannsoporfin
Diseases
GWAS		Erectile dysfunction ( 30583798)
Interacting Genes		66 interacting genes: A2M APP AQP6 ARL13B ASGR2 ATP5F1B BCL2L13 BLOC1S2 CCR2 CD79A CEBPZ CEP126 COPS6 CRB3 CSNK2A1 EBP EEF1G EIF3C ELOVL4 ERGIC3 F2RL1 FAM209A FAM210B GET1 GIT1 GPR152 GPRASP1 GPX8 HAP1 IMMT INPP5K ITFG1 JADE1 KCNJ6 KCNMA1 LAPTM5 LRIF1 MARK3 MED31 MGST3 MTNR1A NDUFS2 NKRF NR3C1 PLXNB2 PTGER4 RBBP4 RETREG3 RNASEK SAR1A SETDB1 SGPL1 SHC1 SKA2 SLC30A8 SMO SNX5 SNX7 SSMEM1 STOM SYT1 TMEM14B TMX2 VMA21 ZFP28 ZNF746	29 interacting genes: ABHD16A ADAM33 AQP6 ARL6IP1 ATP13A1 ATP6V0B BNIP1 CDIPT CLEC12B DAGLA HMOX2 INSIG2 LHFPL5 LYPD6B NINJ2 NIPAL3 ORMDL1 PLLP RTP2 SCD SLC25A46 SLC35E4 TECR THSD7A TMEM107 TMEM60 VAMP2 YIF1A YIPF1
Entrez ID		3163	203547
HPRD ID		00783	18578
Ensembl ID		ENSG00000103415	ENSG00000160131
Uniprot IDs		A0A087WT44 B3KSE0 P30519	Q3ZAQ7
PDB IDs		2Q32 2QPP 2RGZ 4WMH 5UC8 5UC9 5UCA
Enriched GO Terms of Interacting Partners?
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