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HMGB1 and PPP2R3A
Number of citations of the paper that reports this interaction (PubMedID
11748221
)
40
Data Source:
HPRD
(in vitro)
HMGB1
PPP2R3A
Description
high mobility group box 1
protein phosphatase 2 regulatory subunit B''alpha
Image
GO Annotations
Cellular Component
Condensed Chromosome
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Early Endosome
Endoplasmic Reticulum-Golgi Intermediate Compartment
Cell Surface
Transcription Repressor Complex
Secretory Granule Lumen
Alphav-beta3 Integrin-HMGB1 Complex
Neuron Projection
Ficolin-1-rich Granule Lumen
Protein Phosphatase Type 2A Complex
Molecular Function
Four-way Junction DNA Binding
Bubble DNA Binding
Transcription Cis-regulatory Region Binding
Lipopolysaccharide Binding
Phosphatidylserine Binding
Damaged DNA Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Transcription Coactivator Activity
RNA Binding
Double-stranded RNA Binding
Single-stranded RNA Binding
Cytokine Activity
Integrin Binding
Protein Binding
Transcription Factor Binding
DNA Binding, Bending
Calcium-dependent Protein Kinase Regulator Activity
Lyase Activity
C-X-C Chemokine Binding
Protein Kinase Activator Activity
Chemoattractant Activity
RAGE Receptor Binding
DNA Polymerase Binding
Supercoiled DNA Binding
DNA-binding Transcription Factor Binding
Calcium Ion Binding
Protein Binding
Protein Phosphatase Regulator Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Eye Development
Myeloid Dendritic Cell Activation
Endothelial Cell Proliferation
Activation Of Innate Immune Response
Plasmacytoid Dendritic Cell Activation
Macrophage Activation Involved In Immune Response
Dendritic Cell Chemotaxis
Inflammatory Response To Antigenic Stimulus
Regulation Of Tolerance Induction
Regulation Of T Cell Mediated Immune Response To Tumor Cell
DNA Topological Change
Base-excision Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
Regulation Of Transcription By RNA Polymerase II
Autophagy
Inflammatory Response
Signal Transduction
Positive Regulation Of Cytosolic Calcium Ion Concentration
Positive Regulation Of Autophagy
Gene Silencing
Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Lung Development
Neuron Projection Development
Chromatin Assembly
Regulation Of Restriction Endodeoxyribonuclease Activity
Activation Of Protein Kinase Activity
DNA Geometric Change
Positive Regulation Of Mismatch Repair
Negative Regulation Of Interferon-gamma Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-1 Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
V(D)J Recombination
Positive Regulation Of Toll-like Receptor 2 Signaling Pathway
Positive Regulation Of Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Toll-like Receptor 9 Signaling Pathway
T-helper 1 Cell Activation
Endothelial Cell Chemotaxis
Positive Regulation Of Activated T Cell Proliferation
Positive Regulation Of Apoptotic Process
Apoptotic Cell Clearance
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Positive Regulation Of DNA Binding
Positive Regulation Of MAPK Cascade
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
T-helper 1 Cell Differentiation
Innate Immune Response
Positive Regulation Of Myeloid Cell Differentiation
Positive Regulation Of Glycogen Catabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Positive Chemotaxis
Positive Regulation Of DNA Ligation
Response To Glucocorticoid
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Lipopolysaccharide
Positive Regulation Of Monocyte Chemotactic Protein-1 Production
Positive Regulation Of Monocyte Chemotaxis
Positive Regulation Of Wound Healing
Neutrophil Clearance
Cellular Response To Interleukin-7
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Sprouting Angiogenesis
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Negative Regulation Of Apoptotic Cell Clearance
Regulation Of Nucleotide-excision Repair
Positive Regulation Of Dendritic Cell Differentiation
Protein Dephosphorylation
Regulation Of Catalytic Activity
Somite Development
Pathways
ER-Phagosome pathway
Apoptosis induced DNA fragmentation
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Pyroptosis
Regulation of TLR by endogenous ligand
Neutrophil degranulation
Advanced glycosylation endproduct receptor signaling
Advanced glycosylation endproduct receptor signaling
TRAF6 mediated NF-kB activation
Drugs
Chloroquine
Ethyl pyruvate
Diseases
GWAS
Adult body size (
32376654
)
Apolipoprotein A1 levels (
32203549
)
Blood osmolality (transformed sodium) (
28360221
)
Carotid plaque burden (
28282560
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Hippocampal volume (
21116278
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Rapid response to perioperative phenylephrine (change in mean arterial pressure) (
33168928
)
Red blood cell count (
32888494
)
Triglyceride levels (
32203549
32154731
)
Type 2 diabetes (
30297969
)
Urate levels (
31578528
)
Anticoagulant levels (
22216198
)
Atrial fibrillation (
30061737
)
Autism spectrum disorder or schizophrenia (
28540026
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Feeling nervous (
29500382
)
Feeling worry (
29500382
)
Fibrinogen levels (
28107422
26561523
)
General factor of neuroticism (
30867560
)
High density lipoprotein cholesterol levels (
31928498
)
Intraocular pressure (
29617998
)
Liver enzyme levels (gamma-glutamyl transferase) (
33972514
)
Myocardial infarction (
33532862
)
Neurofibrillary tangles (
31497858
)
Neutrophil percentage of white cells (
32888494
)
Schizophrenia (
25056061
29483656
)
Small cell lung carcinoma (
28604730
)
Systolic blood pressure (
31928498
)
Triglyceride levels (
31928498
)
Waist circumference (
31928498
)
Waist circumference adjusted for body mass index (
34021172
25673412
)
Worry too long after an embarrassing experience (
29500382
)
Interacting Genes
123 interacting genes:
ACBD3
AGER
AGTRAP
ALK
AR
ATOH1
C1QBP
C3
CASP3
CCAR1
CCNDBP1
CDK1
CEBPB
CREBBP
CRMP1
CSNK1A1
CTCF
CTNNBL1
CUX1
DLAT
DNAAF2
DNM2
DNMT1
DUX4
EIF1
ENAH
EP300
ERF
ERG28
FIP1L1
FLT1
FOS
FOXA3
FOXC1
GOLM1
GTF2A1
HDLBP
HES1
HMGA1
HNRNPK
HNRNPU
HOXA10
HOXB1
HOXB3
HOXC6
HOXD10
HOXD11
HOXD3
HOXD8
HOXD9
HPF1
HR
HSPA5
IRF2
KRT7
LRIF1
MAP1B
MAPKAPK5
MECP2
MIEN1
MNAT1
MNT
MT2A
NCAN
NEUROD6
NEXN
NFKB1
NR3C1
PCOLCE
PGR
PLAT
PLG
POU5F1
PPP2R3A
PRKCA
PRKDC
PSEN1
PSMA7
PTPN2
PTPRZ1
RAD23B
RAG1
RASAL2
RASSF4
RB1
RBPJ
RELA
RFX1
RPL29
RPS12
RPS20
RSF1
SIX5
SOX18
SPIN1
SPINT1
SRSF3
TAF1
TAF3
TBP
TERF2
TERF2IP
TFE3
TGIF1
TGM3
TLE1
TLE2
TLE5
TLR2
TLR4
TP53
TP73
UBC
UBE2E3
UBE2I
UBXN1
UHRF2
UNC119
WNK4
YY1
ZFP36
ZNF24
ZNF428
9 interacting genes:
AKAP9
ATR
ATXN7L2
CDC6
HMGB1
NPHP3
PPP5C
PTPA
RBL1
Entrez ID
3146
5523
HPRD ID
01228
09225
Ensembl ID
ENSG00000189403
ENSG00000073711
Uniprot IDs
A0A024RDR0
P09429
Q06190
PDB IDs
2LY4
2RTU
2YRQ
6CG0
6CIJ
6CIK
6CIL
6CIM
6OEM
6OEN
6OEO
4I5J
4I5K
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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