HDGF and XBP1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
361

Data Source:
BioGRID (two hybrid)

		HDGF	XBP1
Description		heparin binding growth factor	X-box binding protein 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex Collagen-containing Extracellular Matrix	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Nucleotide Binding Transcription Corepressor Binding Double-stranded DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity RNA Binding Growth Factor Activity Heparin Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Signal Transduction Cellular Response To Interleukin-7	Angiogenesis Liver Development Positive Regulation Of Immunoglobulin Production Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Fatty Acid Biosynthetic Process Autophagy Apoptotic Process Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Muscle Organ Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Myotube Differentiation Protein Transport Positive Regulation Of Cell Migration Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Nutrient Positive Regulation Of Interleukin-6 Production Cellular Response To Insulin Stimulus Cellular Triglyceride Homeostasis Positive Regulation Of Vascular Wound Healing IRE1-mediated Unfolded Protein Response Cellular Response To Glucose Starvation Cholesterol Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Neuron Development Fatty Acid Homeostasis Sterol Homeostasis Adipose Tissue Development Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Fructose Stimulus Cellular Response To Glucose Stimulus Cellular Response To Interleukin-4 Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Plasma Cell Differentiation Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Lactation Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Hepatocyte Proliferation
Pathways		XBP1(S) activates chaperone genes
Drugs		Copper
Diseases
GWAS		Blood protein levels ( 30072576) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Refractive error ( 32231278)	Esophageal cancer (squamous cell) ( 22960999) Esophageal squamous cell carcinoma ( 25129146) Heel bone mineral density ( 28869591) Mean arterial pressure ( 29403010) Pancreatic cancer ( 25086665) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		6 interacting genes: APP GPR37 JUN SMAD4 TRAF7 XBP1	22 interacting genes: ATF6 ATF6B CREBZF ESR1 FOS FUBP3 GLI1 H1-0 H1-10 HDGF MDM2 MTNR1B NR0B2 PCBD2 RBL2 SRSF1 SSX4 TRIP4 UBE2I UBE2V1 ZNF440 ZNF580
Entrez ID		3068	7494
HPRD ID		02079	01908
Ensembl ID		ENSG00000143321	ENSG00000100219
Uniprot IDs		A0A384NPW1 A8K8G0 B7Z958 P51858	A0A024R1F0 P17861
PDB IDs		1RI0 2NLU	6R5Q 6R6G 6R6P 6R7Q
Enriched GO Terms of Interacting Partners?
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