HDAC1 and HDAC2

Number of citations of the paper that reports this interaction (PubMedID 9520398)
127

Data Source:
HPRD (in vitro, in vivo)

		HDAC1	HDAC2
Description		histone deacetylase 1	histone deacetylase 2
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Heterochromatin Nucleus Nucleoplasm Cytoplasm Cytosol Sin3 Complex NuRD Complex Transcription Repressor Complex Protein-containing Complex Neuron Projection Neuronal Cell Body Perinuclear Region Of Cytoplasm	Histone Deacetylase Complex Chromatin Nucleus Nucleoplasm Cytoplasm Sin3 Complex NuRD Complex Protein-containing Complex ESC/E(Z) Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding P53 Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Deacetylase Activity Enzyme Binding Nucleosomal DNA Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Krueppel-associated Box Domain Binding Histone Deacetylase Binding Protein N-terminus Binding NF-kappaB Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding DNA-binding Transcription Factor Binding Promoter-specific Chromatin Binding	Chromatin Binding RNA Binding Histone Deacetylase Activity Protein Binding Transcription Factor Binding Deacetylase Activity Enzyme Binding Heat Shock Protein Binding Nucleosomal DNA Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Histone Deacetylase Binding Sequence-specific DNA Binding NF-kappaB Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Amphetamine Chromatin Organization Chromatin Remodeling DNA Methylation-dependent Heterochromatin Assembly Regulation Of Transcription By RNA Polymerase II Protein Deacetylation Endoderm Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Epidermal Cell Differentiation Negative Regulation Of Gene Expression Negative Regulation Of Myotube Differentiation Histone Deacetylation Hippocampus Development Neuron Differentiation Response To Caffeine Response To Lipopolysaccharide Positive Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production Circadian Regulation Of Gene Expression Cellular Response To Oxidative Stress Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Neuron Apoptotic Process Negative Regulation By Host Of Viral Transcription Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Secretion Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Endopeptidase Activity Response To Hyperoxia Negative Regulation Of Androgen Receptor Signaling Pathway Hair Follicle Placode Formation Eyelid Development In Camera-type Eye Fungiform Papilla Formation Histone H3 Deacetylation Histone H4 Deacetylation Cellular Response To Tumor Necrosis Factor Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Amyloid-beta Clearance Positive Regulation Of Signaling Receptor Activity Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Response To Amphetamine Cardiac Muscle Hypertrophy Chromatin Remodeling Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Epidermal Cell Differentiation Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Neuron Projection Development Dendrite Development Histone Deacetylation Response To Caffeine Response To Lipopolysaccharide Positive Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production Circadian Regulation Of Gene Expression Positive Regulation Of Collagen Biosynthetic Process Cellular Response To Heat Response To Nicotine Response To Cocaine Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Behavioral Response To Ethanol Positive Regulation Of Oligodendrocyte Differentiation Response To Hyperoxia Hair Follicle Placode Formation Negative Regulation Of Dendritic Spine Development Eyelid Development In Camera-type Eye Fungiform Papilla Formation Cellular Response To Hydrogen Peroxide Histone H3 Deacetylation Histone H4 Deacetylation Cellular Response To Retinoic Acid Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Male Mating Behavior Cellular Response To Dopamine Positive Regulation Of Signaling Receptor Activity Negative Regulation Of Peptidyl-lysine Acetylation
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 p75NTR negatively regulates cell cycle via SC1 Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Deactivation of the beta-catenin transactivating complex ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression SUMOylation of chromatin organization proteins Repression of WNT target genes Repression of WNT target genes Regulation of TP53 Activity through Acetylation G1/S-Specific Transcription RNA Polymerase I Transcription Initiation RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN gene transcription Regulation of PTEN gene transcription Estrogen-dependent gene expression Loss of MECP2 binding ability to 5mC-DNA Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels MECP2 regulates transcription of neuronal ligands FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Potential therapeutics for SARS STAT3 nuclear events downstream of ALK signaling Factors involved in megakaryocyte development and platelet production	p75NTR negatively regulates cell cycle via SC1 NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression SUMOylation of chromatin organization proteins Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination Potential therapeutics for SARS STAT3 nuclear events downstream of ALK signaling Factors involved in megakaryocyte development and platelet production
Drugs		Arsenic trioxide Zinc Vorinostat Belinostat Pracinostat Romidepsin Panobinostat Fingolimod Mocetinostat Abexinostat Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Pravastatin Lovastatin Theophylline Valproic acid Simvastatin Atorvastatin Fluvastatin Aminophylline Oxtriphylline Vorinostat Belinostat Pracinostat Romidepsin Panobinostat Tixocortol Mocetinostat
Diseases
GWAS			Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Metabolite levels ( 23823483)
Interacting Genes		191 interacting genes: APEX1 AR ARID4A ATF3 ATRX BAZ2A BCL11A BCL3 BCL6 BCL6B BCOR BHLHE40 BRCA1 BRMS1 BRMS1L BUB1 BUB1B BUB3 CBFA2T3 CCN5 CDC20 CDH1 CDKN1A CDYL CHD1 CHD4 CHFR CIITA CREBBP CREM CSNK2A1 CSNK2A2 CTBP1 CYTOR DAXX DDB2 DDX17 DHX30 DNMT1 DNMT3A DNMT3B DNMT3L EED EID2 EID2B ELK1 ENO1 EP300 ERCC6 EZH2 FKBP3 FOXG1 FRA10F GATA3 GCM1 GPS2 H2AC1 H3-4 H3C1 HBP1 HDAC2 HDAC3 HDAC7 HDAC9 HELLS HEY2 HIC1 HIF1A HIF1AN HNRNPD HR HUS1 ICAM1 IKZF1 ING1 IRF5 JDP2 KAT5 KCTD11 KDM1A KLF1 KLF11 KLF4 KLF5 LCOR MAD1L1 MAGEA1 MBD2 MBD3 MBD3L2 MBD4 MDM2 MECOM MECP2 MEN1 MIER1 MORF4L2 MTA1 MXD1 MYOD1 NCOR2 NFE4 NFKB1 NFKBIA NKX2-5 NKX3-2 NR1D2 NR2E3 NR2F2 NR3C1 NRIP1 NUP98 OGT PARP1 PCNA PEX14 PHB PHB2 PHF12 PHF21A PIAS3 PIAS4 PITX2 PML PPARD PPARG PPP2R1B PRKACA PRKG1 PRRG4 PTMA RAD9A RAP1A RARA RB1 RBBP4 RBBP7 RBL1 RBL2 RBP1 RBPJ RELA REPIN1 RFC1 RFC4 RUNX1T1 RUNX3 RUVBL2 SALL1 SAP18 SAP30 SATB1 SATB2 SENP1 SERPINB5 SETDB1 SIN3A SIN3B SMAD2 SMAD3 SOX6 SP1 SP3 SPEN SPI1 STAT2 STAT3 SUDS3 SUMO2 SUV39H1 SYK TAB2 TAL1 TFCP2 TGIF1 TGIF2 THAP11 TNIP1 TOP2A TOP2B TP53 TPD52L1 TRIM27 TXNIP UBE2I USP38 USP43 VHL ZBTB16 ZMYND11 ZNF76	106 interacting genes: ANTXR1 APPL1 ARID4A AURKA BCL11A BRCA1 BRMS1 BRMS1L BUB3 CABIN1 CDC20 CDH1 CDKN1A CDYL CHD3 CHFR CIR1 CSNK2A1 CSNK2A2 CTBP1 CYTOR DAXX DDX20 DMAP1 DNMT1 DNMT3B EED EID2 ERCC6 FKBP3 FOXO3 FTCD FYN GATA3 H2AC1 H2AC20 H2BC21 H3-4 H3C1 HDAC1 HDAC10 HDAC7 HIF1A HIF1AN HOPX HUWE1 IFRD1 IKZF1 IKZF4 ING1 LAMA4 MAD1L1 MBD2 MBD3L2 MEN1 MTA1 MXD1 NACC2 NRIP1 PA2G4 PADI4 PHB2 PHF21A PIAS4 PML PPARD PPP1R8 PTMA RBBP4 RBBP7 RBP1 RCOR1 RELA REV3L RFX5 RUNX3 SALL1 SAP30 SETDB1 SIN3A SMAD2 SMARCA5 SMYD1 SNW1 SP1 SP3 SPEN SS18L1 STAT3 STK25 SUMO2 SUV39H1 SYK TFCP2 THRA THRB TNS4 TOP2A TOP2B TP53 TREML2 USP4 VHL YY1 ZBTB16 ZNF461
Entrez ID		3065	3066
HPRD ID		03143	05521
Ensembl ID		ENSG00000116478	ENSG00000196591
Uniprot IDs		Q13547 Q6IT96	Q92769
PDB IDs		1TYI 4BKX 5ICN 6Z2J 6Z2K 7AO8 7AO9 7AOA	3MAX 4LXZ 4LY1 5IWG 5IX0 6G3O 6WBW 6WBZ 6XDM 6XEB 6XEC 7KBG 7KBH
Enriched GO Terms of Interacting Partners?
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