HBZ and UPF2

Number of citations of the paper that reports this interaction (PubMedID 15231747)
57

Data Source:
BioGRID (two hybrid)

		HBZ	UPF2
Description		hemoglobin subunit zeta	UPF2 regulator of nonsense mediated mRNA decay
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GO Annotations	Cellular Component	Hemoglobin Complex Haptoglobin-hemoglobin Complex Extracellular Exosome	Nucleus Cytoplasm Cytosol Polysome Exon-exon Junction Complex Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm
	Molecular Function	Peroxidase Activity Oxygen Carrier Activity Iron Ion Binding Protein Binding Oxygen Binding Heme Binding Haptoglobin Binding Organic Acid Binding	RNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Oxygen Transport Hydrogen Peroxide Catabolic Process Cellular Oxidant Detoxification	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Liver Development MRNA Export From Nucleus Animal Organ Regeneration
Pathways			Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Body mass index ( 26426971) Early cardiac repolarization ( 31600170) Hemoglobin ( 32888494) Hemoglobin levels ( 26366553) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 29403010 27863252) Red blood cell count ( 29403010 32888494)	Diverticular disease ( 30177863)
Interacting Genes		29 interacting genes: APP CARD10 CCNDBP1 CYSRT1 DOCK8 FGFR3 GOLGA6L9 HBB HBD HBE1 HBM HBQ1 HNRNPD HNRNPK IKBKG KHDRBS2 KHDRBS3 KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 MTUS2 NBPF19 NOTCH2NLA NTAQ1 RBMY1A1 SP1 UPF2	78 interacting genes: ABCF2 AGPAT1 AKTIP ART4 ATP1B3 BLM CALR CENPU CIZ1 COMTD1 CYBA DCP1B DCP2 DPF2 E4F1 EIF1 EIF4A1 EIF4G1 ENO1 EXOSC1 EXOSC10 EXOSC4 EXOSC6 EXOSC8 GADD45GIP1 GATA3 HBZ HMGA1 HS3ST3A1 HSF2BP ITGB1 KRT18 LDHA LSM1 MAP1A MAP1LC3B MIF MRPL40 MTERF3 MTREX MYB NDUFA7 NOB1 NOMO1 NOP53 PHB2 PITX1 PUF60 RNPS1 RPL13 RPL5 RPL8 RPS15 RPS25 RPS6 RPS7 RRP7A RSRC2 SERBP1 SERF2 SMG1 SSBP2 SUMO3 TK1 TNNI2 TOP3B TUBB2A TYMS UPF1 UPF3B WNK1 XRN1 XRN2 ZBTB48 ZFP36 ZGPAT ZNF408 ZNF44
Entrez ID		3050	26019
HPRD ID		00794	10405
Ensembl ID		ENSG00000130656	ENSG00000151461
Uniprot IDs		P02008	Q9HAU5
PDB IDs		1JEB 3W4U	1UW4 2WJV 4CEK 4CEM
Enriched GO Terms of Interacting Partners?
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