NOP53 and TSPYL2

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		NOP53	TSPYL2
Description		NOP53 ribosome biogenesis factor	TSPY like 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Nucleolus Cytosol RDNA Heterochromatin Intracellular Membrane-bounded Organelle	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	P53 Binding RNA Binding Protein Binding 5S RRNA Binding Identical Protein Binding	RDNA Binding Chromatin Binding Protein Binding Histone Binding
	Biological Process	Ribosomal Large Subunit Assembly Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Phosphorylation DNA Repair RRNA Processing Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of RIG-I Signaling Pathway Regulation Of Apoptotic Process Protein Stabilization Regulation Of Cell Cycle Negative Regulation Of Protein Kinase B Signaling Cellular Response To Hypoxia Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Protein Localization To Nucleolus Positive Regulation Of Protein K63-linked Deubiquitination Regulation Of Aerobic Respiration Protein Localization To Nucleoplasm	Nucleosome Assembly Cell Cycle Negative Regulation Of DNA Replication Regulation Of Signal Transduction Negative Regulation Of Cell Growth Negative Regulation Of Cell Cycle Regulation Of Protein Kinase Activity
Pathways			XBP1(S) activates chaperone genes
Drugs
Diseases
GWAS
Interacting Genes		14 interacting genes: CCDC136 CDKN2A CEP70 HAP1 HMGB2 MDM2 OGT PPP1CA PSMA1 SPTBN1 SRPK2 TP53 TSPYL2 UPF2	46 interacting genes: ABT1 AEBP2 APTX CASK CCNB1 CDK1 CDK2 CDK4 CEP19 COIL CREBBP CSNK2A1 EEF1A1 GFI1B H2BC15 HMGXB4 INO80B KMT5B LMO2 LNX1 MCRS1 NOL12 NOP53 PHF19 RBM15 RNF151 RPS25 SIRT6 SNIP1 TBC1D26 TMA16 TNNT1 TSPYL1 XAGE1A XAGE1B ZBTB24 ZBTB48 ZFP1 ZFP91 ZNF280C ZNF286A ZNF329 ZNF524 ZNF687 ZNF775 ZNF835
Entrez ID		29997	64061
HPRD ID		16142	06713
Ensembl ID		ENSG00000105373	ENSG00000184205
Uniprot IDs		Q9NZM5	Q9H2G4
PDB IDs
Enriched GO Terms of Interacting Partners?
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