GYS2 and TNFRSF1A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		GYS2	TNFRSF1A
Description		glycogen synthase 2	TNF receptor superfamily member 1A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Cell Cortex Cortical Actin Cytoskeleton Ectoplasm	Golgi Membrane Tumor Necrosis Factor Receptor Superfamily Complex Extracellular Region Extracellular Space Mitochondrion Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Receptor Complex Membrane Raft
	Molecular Function	Glycogen (starch) Synthase Activity Glycogen Synthase Activity, Transferring Glucose-1-phosphate	Tumor Necrosis Factor-activated Receptor Activity Protein Binding Tumor Necrosis Factor Binding
	Biological Process	Glycogen Biosynthetic Process Generation Of Precursor Metabolites And Energy Response To Glucose	Aortic Valve Development Pulmonary Valve Development Negative Regulation Of Extracellular Matrix Constituent Secretion Prostaglandin Metabolic Process Inflammatory Response Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cardiac Muscle Hypertrophy Cytokine-mediated Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Cellular Response To Mechanical Stimulus Protein Localization To Plasma Membrane Positive Regulation Of Apoptotic Process Involved In Morphogenesis Regulation Of Establishment Of Endothelial Barrier
Pathways		Glycogen synthesis Glycogen storage disease type 0 (liver GYS2) Glycogen storage disease type IV (GBE1)	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR1-mediated ceramide production TNFs bind their physiological receptors Interleukin-10 signaling TNF signaling
Drugs			6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2',3':4,5]Pyrrolo[1,2-C]Imidazol-7-One Tasonermin
Diseases
GWAS		Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Fasting insulin ( 34059833) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)	Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) ( 23648065) Alopecia areata ( 25608926) Ankylosing spondylitis ( 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Colorectal cancer ( 24836286) Crohn's disease ( 26192919) Eosinophil counts ( 32888494) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494 27863252) Multiple sclerosis ( 31604244 24076602 19525953 21833088 27386562) Neutrophil percentage of white cells ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Primary biliary cholangitis ( 28425483 21399635 26394269) Primary biliary cirrhosis ( 22961000) White blood cell count ( 32888494)
Interacting Genes		4 interacting genes: GYG2 MDM2 TNFRSF1A TP53	67 interacting genes: ADAM17 AKT1 ATF6 BAG4 BCL10 CASP10 CASP7 CCND2 CDK6 CDKN2B CHUK CLIP3 CSNK1A1L DAPK1 DAXX EGFR ERAP1 ERN1 FANCD2 GRB2 GYS2 HRG HSP90AA1 HSPA8 IKBKB IKBKG JAK1 JAK2 LTA LTB MADD MAGEH1 MAPK1 MOAP1 MYOC NSMAF PIP4K2B PRDX3 PRKCD PSMD2 PTK2 PTPN11 PTPN6 RACK1 RASSF1 RIPK1 RIPK2 RIPK3 SGTA SRC STAMBP STAT1 STK11 SUMO1 SYK TNF TNFRSF25 TNFSF13 TRADD TRAF1 TRAF2 TRAF3 TRAP1 TRPC4AP UBE2I UBQLN1 UCHL1
Entrez ID		2998	7132
HPRD ID		00722	01861
Ensembl ID		ENSG00000111713	ENSG00000067182
Uniprot IDs		P54840	J9PH39 P19438
PDB IDs			1EXT 1FT4 1ICH 1NCF 1TNR 7K7A 7KP7 7KP8 7KPB
Enriched GO Terms of Interacting Partners?
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