DNMT3L and NR2E1

Number of citations of the paper that reports this interaction (PubMedID 24952347)
14

Data Source:
BioGRID (pull down)

		DNMT3L	NR2E1
Description		DNA methyltransferase 3 like	nuclear receptor subfamily 2 group E member 1
Image
GO Annotations	Cellular Component	Nucleus Cytosol	Chromatin Nucleoplasm
	Molecular Function	Protein Binding Enzyme Activator Activity Enzyme Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Steroid Hormone Receptor Activity Nuclear Receptor Activity Zinc Ion Binding Histone Deacetylase Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Methylation Regulation Of Gene Expression By Genetic Imprinting Male Meiosis I Spermatogenesis DNA Methylation On Cytosine DNA Methylation Involved In Gamete Generation Negative Regulation Of Transcription, DNA-templated Stem Cell Differentiation Regulation Of Catalytic Activity Negative Regulation Of DNA Methylation Positive Regulation Of DNA Methylation	Negative Regulation Of Transcription By RNA Polymerase II Behavioral Fear Response Aggressive Behavior Regulation Of Transcription By RNA Polymerase II Nervous System Development Visual Perception Dentate Gyrus Development Amygdala Development Olfactory Bulb Development Layer Formation In Cerebral Cortex Forebrain Generation Of Neurons Cerebral Cortex Neuron Differentiation Anterior Commissure Morphogenesis Cell Differentiation Extracellular Matrix Organization Intracellular Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Social Behavior Negative Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Cell Fate Commitment Negative Regulation Of Neuron Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Astrocyte Differentiation Regulation Of Dendrite Morphogenesis Anatomical Structure Development Retina Development In Camera-type Eye Regulation Of Timing Of Neuron Differentiation Long-term Synaptic Potentiation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Stem Cell Proliferation
Pathways		DNA methylation	Nuclear Receptor transcription pathway Regulation of PTEN gene transcription
Drugs
Diseases
GWAS
Interacting Genes		78 interacting genes: - ASH2L ATF1 ATF2 ATF3 ATF4 BLZF1 CDX2 CREB1 CREBL2 CREM DDIT3 DLX4 DMTF1 DNMT3A DNMT3B DR1 E2F3 E2F5 E2F6 EGR1 EGR2 EGR4 ESR1 ESR2 ETS1 F2RL1 FOS FOSB FOSL1 FOSL2 GATA1 GMEB1 GSK3B GTF2H2 GTF2I GTF3C5 H2AC20 H2BC21 H3C14 H4C14 HAND1 HAND2 HDAC1 HNF4G HOXA5 HOXC11 ID1 JUN JUNB KLF12 LDB1 LHX2 MAFK MECP2 MED7 MEF2A MEF2D NFIL3 NFKB1 NR1H2 NR1I2 NR1I3 NR2E1 NR3C1 NR6A1 NUDT21 PDZD4 PHPT1 RELA RSL24D1 RXRA SMAD1 SMAD3 SMAD4 TLE5 TP53 YY1	7 interacting genes: ATN1 DNMT3L ERBIN KDM1A NSD1 RAB27B RERE
Entrez ID		29947	7101
HPRD ID		09417	07230
Ensembl ID		ENSG00000142182	ENSG00000112333
Uniprot IDs		Q9UJW3	B6ZGT9 Q9Y466
PDB IDs		2PV0 2PVC 2QRV 4U7P 4U7T 5YX2 6BRR 6F57 6KDA 6KDB 6KDL 6KDP 6KDT 6U8P 6U8V 6U8W 6U8X 6U90 6U91 6W89 6W8B 6W8D 6W8J	4XAJ
Enriched GO Terms of Interacting Partners?
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