GTF2I and AP4S1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		GTF2I	AP4S1
Description		general transcription factor IIi	adaptor related protein complex 4 subunit sigma 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane	AP-4 Adaptor Complex Endosome Lumen Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of DNA Repair By Transcription From RNA Polymerase II Promoter	Protein Targeting Protein Localization Vesicle-mediated Transport
Pathways			Lysosome Vesicle Biogenesis
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737 29892015) C-reactive protein levels ( 30388399) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30224653) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Menarche (age at onset) ( 25231870) SjÃ¶gren's syndrome ( 24097066 27503288) Systemic lupus erythematosus ( 32771030 28714469)	Brain morphology (MOSTest) ( 32665545) Mean corpuscular volume ( 32888494) Systolic blood pressure ( 33230300)
Interacting Genes		46 interacting genes: AP1B1 AP2B1 AP4S1 ATF6 BCL2L11 BTK C4BPA CALM1 CTAG1A CTAG1B DNMT3L DPY30 ERCC6 GCC1 HDAC3 JAK2 LINC01554 LSM8 MAP3K3 MAPK12 MAPK3 MTUS2 MYC NFKB2 PIAS2 PJA1 POU2AF1 PRKG1 PRRX1 SLU7 SMAD2 SNRPN SRC SRF STAT1 STAT3 SUMO2 TAB2 TRAF6 TRIM54 UBC UBE2I USF1 YY1 ZBTB17 ZMYM3	6 interacting genes: AFP APP GRB2 GTF2I HTR6 TEAD3
Entrez ID		2969	11154
HPRD ID		03399	06257
Ensembl ID		ENSG00000263001	ENSG00000100478
Uniprot IDs		A8K9W7 P78347 Q499G6 X5D2J9 X5D939 X5DNP5 X5DR09	Q9Y587
PDB IDs		2D9B 2DN4 2ED2 2EJE
Enriched GO Terms of Interacting Partners?
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