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GTF2A1 and PSMC6
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
86
Data Source:
BioGRID
(two hybrid)
GTF2A1
PSMC6
Description
general transcription factor IIA subunit 1
proteasome 26S subunit, ATPase 6
Image
GO Annotations
Cellular Component
Nucleoplasm
Transcription Factor TFIID Complex
Transcription Factor TFIIA Complex
Cytosol
Transcription Preinitiation Complex
Proteasome Complex
Nucleus
Nucleoplasm
Cytosol
Proteasome Regulatory Particle, Base Subcomplex
Membrane
Inclusion Body
Proteasome Accessory Complex
Cytosolic Proteasome Complex
Extracellular Exosome
Molecular Function
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
DNA Binding
Protein Binding
Transcription Factor Binding
RNA Polymerase II General Transcription Initiation Factor Activity
TBP-class Protein Binding
Protein Heterodimerization Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Protein Binding
ATP Binding
Protein-macromolecule Adaptor Activity
Proteasome-activating Activity
Identical Protein Binding
Biological Process
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Ubiquitin-dependent ERAD Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Positive Regulation Of Inclusion Body Assembly
Positive Regulation Of Proteasomal Protein Catabolic Process
Pathways
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
RNA Polymerase II Pre-transcription Events
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Initiation And Promoter Clearance
Estrogen-dependent gene expression
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
ROS sensing by NFE2L2
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Apolipoprotein A1 levels (
32203549
)
HDL cholesterol levels (
32203549
)
Neutrophil count (
32888494
)
Night sleep phenotypes (
27126917
)
Thyroid stimulating hormone levels (
32769997
)
White blood cell count (
32888494
)
Prostate cancer (
23535732
)
Interacting Genes
27 interacting genes:
BCL3
BIRC7
CREB1
CSNK2A1
CSNK2A2
GTF2A2
GTF2E1
GTF2E2
GTF2F1
HMGB1
HNRNPLL
NCOA6
NFYA
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PSMC6
SP4
TAF1
TAF4
TAF4B
TASP1
TBP
TBPL1
TRIP4
23 interacting genes:
BYSL
C1orf216
CCDC146
CCDC85B
CCT2
CDC37
CDC42
CRK
CRKL
CYB5R2
GTF2A1
PAAF1
PSMA6
PSMC2
PSMC3
PSMC4
PSMC5
PSMD13
PSMD9
SDCBP
SEC14L5
SMARCE1
UBE2I
Entrez ID
2957
5706
HPRD ID
02748
04086
Ensembl ID
ENSG00000165417
ENSG00000100519
Uniprot IDs
P52655
A0A087X2I1
P62333
PDB IDs
1NVP
5FUR
5IY6
5IY7
5IY8
5IY9
5IYA
5IYB
5IYC
5IYD
5M4S
6MZM
6O9L
5GJQ
5GJR
5L4G
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHJ
5VHM
5VHN
5VHO
5VHP
5VHQ
5VHR
5VHS
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6WJD
6WJN
Enriched GO Terms of Interacting Partners
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