CXCL3 and CXCR1

Number of citations of the paper that reports this interaction (PubMedID 8702798)
100

Data Source:
HPRD (in vivo, in vitro)

		CXCL3	CXCR1
Description		C-X-C motif chemokine ligand 3	C-X-C motif chemokine receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Secretory Granule Membrane
	Molecular Function	Chemokine Activity CXCR Chemokine Receptor Binding	Interleukin-8 Receptor Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Interleukin-8 Binding
	Biological Process	Inflammatory Response Neutrophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide	Dendritic Cell Chemotaxis Immune Response Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Neutrophil Chemotaxis Receptor Internalization Interleukin-8-mediated Signaling Pathway Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation
Drugs			Ketoprofen
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Urate levels (BMI interaction) ( 25811787)	Basophil count ( 32888494) Diffusing capacity of carbon monoxide ( 30694715) Idiopathic intracranial hypertension ( 29608535) Inflammatory bowel disease ( 28067908 23128233) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 29403010) Smooth-surface caries ( 23470693) White blood cell count ( 29403010)
Interacting Genes		6 interacting genes: CCL11 CXCL5 CXCL6 CXCR1 CXCR2 XCL2	21 interacting genes: ADRA1A CDK1 CLDND1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR2 FATE1 GNA14 GNA15 GNAI2 IGFBP5 PDCD6IP PPBP TRARG1 TUBA1A TUBA4A UBE2C
Entrez ID		2921	3577
HPRD ID		00742	00908
Ensembl ID		ENSG00000163734	ENSG00000163464
Uniprot IDs		P19876	P25024
PDB IDs			1ILP 1ILQ 2LNL
Enriched GO Terms of Interacting Partners?
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