GRM7 and NGLY1

		GRM7	NGLY1
Description		glutamate metabotropic receptor 7	N-glycanase 1
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Integral Component Of Membrane Axon Dendrite Asymmetric Synapse Dendritic Shaft Receptor Complex Postsynaptic Membrane Presynaptic Active Zone	Nucleus Cytoplasm Cytosol
	Molecular Function	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity Group III Metabotropic Glutamate Receptor Activity Glutamate Receptor Activity Adenylate Cyclase Inhibitor Activity Protein Dimerization Activity Serine Binding	Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Protein Binding Metal Ion Binding
	Biological Process	Behavioral Fear Response Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Sensory Perception Of Sound Negative Regulation Of Glutamate Secretion Regulation Of Cyclase Activity Negative Regulation Of Catalytic Activity Regulation Of Synaptic Transmission, Glutamatergic Axon Development Glycosylation	Protein Folding Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Glycoprotein Catabolic Process Protein Deglycosylation ER-associated Misfolded Protein Catabolic Process
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)	N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Drugs		Glutamic acid
Diseases
GWAS		Acute kidney injury in coronary artery bypass surgery (creatinine rise) ( 26083657) Adverse response to chemotherapy (neutropenia/leucopenia) (all topoisomerase inhibitors) ( 23648065) Airway imaging phenotypes ( 26030696) Chronotype ( 30696823) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Cognitive function in longevity ( 33607172) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 30224653) Early response to risperidone in schizophrenia ( 26856250) HDL cholesterol levels in HIV infection ( 33109212) Major depressive disorder (broad) ( 20038947) Night sleep phenotypes ( 27126917) Orofacial clefts ( 22419666) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Panic disorder ( 19165232) Personality traits in bipolar disorder ( 21368711) Plasma clusterin levels ( 26545630) Platelet reactivity in response to clopidogrel treatment ( 32472697) Recurrent major depressive disorder ( 29317602) Response to fenofibrate (total cholesterol levels) ( 27002377) Systemic sclerosis ( 30247649) Telomere length ( 30185882) Urate levels in lean individuals ( 25811787) Urinary albumin excretion ( 32277301) Uterine fibroid number (single vs multiple) ( 30196971) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		15 interacting genes: CALM1 CALM2 CALM3 FLNA GNAQ GRIP1 GRIPAP1 NGLY1 PICK1 SDCBP TUBA1A TUBA1B TUBA3C TUBA4A TUBA8	25 interacting genes: APP BICRAL FAF1 GJB2 GRM7 GUCD1 LIMD1 MAP3K2 NPAS2 NSFL1C OPA3 PAX5 PAX6 PROC RAD23A RAD23B SH3BP1 SRPK2 TCF12 TRAFD1 TRIM54 UBQLN1 UBXN2B VCP VMAC
Entrez ID		2917	55768
HPRD ID		04979	10118
Ensembl ID		ENSG00000196277	ENSG00000151092
Uniprot IDs		B2R693 B9EGG9 Q14831 Q59G95	Q96IV0
PDB IDs		3MQ4 5C5C	2CCQ 2CM0
Enriched GO Terms of Interacting Partners?
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