ANKRD11 and BRCC3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ANKRD11	BRCC3
Description		ankyrin repeat domain 11	BRCA1/BRCA2-containing complex subunit 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Ubiquitin Ligase Complex Nuclear Ubiquitin Ligase Complex Spindle Pole Nucleus Nucleoplasm Cytoplasm Cytosol BRCA1-A Complex BRISC Complex
	Molecular Function		Thiol-dependent Deubiquitinase Protein Binding Metallopeptidase Activity Enzyme Regulator Activity Polyubiquitin Modification-dependent Protein Binding Metal Ion Binding Lys63-specific Deubiquitinase Activity Isopeptidase Activity
	Biological Process	Anatomical Structure Morphogenesis Odontogenesis Of Dentin-containing Tooth Skeletal System Morphogenesis Face Morphogenesis	Double-strand Break Repair Mitotic G2 DNA Damage Checkpoint Signaling Response To X-ray Response To Ionizing Radiation Protein Deubiquitination Positive Regulation Of DNA Repair Regulation Of Catalytic Activity Cell Division Protein K63-linked Deubiquitination Histone H2A K63-linked Deubiquitination
Pathways			Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs			Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Eosinophil counts ( 32888494) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Lymphocyte counts ( 32888494 27863252) Waist circumference adjusted for body mass index ( 34021172)	Venous thromboembolism ( 31676865)
Interacting Genes		93 interacting genes: ABHD11 AGR2 ANKRD33 ARID3A ARID5A BHLHB9 BRCC3 C10orf82 C11orf1 C18orf54 C1QTNF2 CALCA CCDC196 CCHCR1 CCN3 CDC23 CDCA7L CDR2L CEP44 COG4 DEPTOR FAM136A FAM221B FOLR3 FTO GOLGA2 GOLGA6L9 GRIPAP1 HAUS3 HDAC3 HDAC4 HDAC5 HOMEZ HOOK2 HRAS IGFBP6 IKZF1 ITGB3BP KANK2 KPNA3 KPNA6 KRT34 LZTS2 MKRN3 MTFR1L MTUS2 MXRA8 MYF5 NAB2 NCOA1 NCOA2 NCOA3 NOTO NTAQ1 PDE4DIP PIH1D2 PLAGL2 PPARA RAC3 RCOR3 RINT1 RPH3AL RSPO4 RUBCN SERTAD3 SNRNP35 SPANXN2 SPATA2 SPRY1 SRC STMN3 STRA8 SYTL3 TADA2B TFIP11 TLE5 TNNI1 TRAF2 TRIM37 TRIM54 TSPOAP1 TTC23L TXN UFC1 USH1G USP54 USP6 VDR ZNF426 ZNF552 ZNF655 ZNF688 ZRANB1	12 interacting genes: ANKRD11 BRCA1 FANCG ICOS IFNAR1 NUMA1 SHMT2 SNAPC5 SUMO2 UBC UBE2D1 UIMC1
Entrez ID		29123	79184
HPRD ID		12456	06465
Ensembl ID		ENSG00000167522	ENSG00000185515
Uniprot IDs		Q6UB99	P46736
PDB IDs			6H3C 6R8F
Enriched GO Terms of Interacting Partners?
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