TRARG1 and CXCR2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TRARG1	CXCR2
Description		trafficking regulator of GLUT4 (SLC2A4) 1	C-X-C motif chemokine receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Endomembrane System Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane Perinuclear Region Of Cytoplasm	Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Microtubule Cytoskeleton Membrane Secretory Granule Membrane Mast Cell Granule Mitotic Spindle
	Molecular Function		Interleukin-8 Receptor Activity G Protein-coupled Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding Interleukin-8 Binding
	Biological Process	Cellular Response To Insulin Stimulus Glucose Import In Response To Insulin Stimulus Protein Localization To Plasma Membrane Endosome To Plasma Membrane Protein Transport	Dendritic Cell Chemotaxis Acute Inflammatory Response To Antigenic Stimulus Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Calcium-mediated Signaling Neutrophil Chemotaxis Midbrain Development Receptor Internalization Negative Regulation Of Neutrophil Apoptotic Process Interleukin-8-mediated Signaling Pathway Neutrophil Activation Positive Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Cell Chemotaxis Chemokine-mediated Signaling Pathway Metanephric Tubule Morphogenesis Positive Regulation Of Neutrophil Chemotaxis
Pathways			Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation
Drugs
Diseases
GWAS			Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Smooth-surface caries ( 23470693) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)
Interacting Genes		101 interacting genes: APH1A APH1B AQP12B AQP2 ARL13B BCL2L13 BIK BSCL2 C6orf89 CCR4 CD300E CD53 CD79A CLDN12 CLDN7 CLDN8 CLEC10A CXCR1 CXCR2 DAGLA EBP EFNA4 ELOVL4 ERGIC3 FNDC9 FUT3 GJB3 GPR151 GPR42 GPR61 GPRC5D HSF2BP IFNGR2 IL3RA IRF1-AS1 KASH5 KCNC1 KRT34 KRTAP5-9 LAPTM4B LHFPL5 LY6E MEOX2 MFF MFSD14B MRM1 MRPS18B MTIF3 NPFFR2 NPY2R ODF4 OPN1LW OPRM1 OR7D4 OSTC PDZK1IP1 PLEKHB2 PSCA RHBDL1 RHCG RTP4 SCN3B SDCBP SGPL1 SLC10A1 SLC13A4 SLC14A2 SLC16A2 SLC1A5 SLC30A2 SLC34A2 SLC35F1 SLC36A1 SLC38A1 SLC38A11 SLC38A6 SLC39A1 SLC7A1 SLC7A14 SLCO3A1 SPAG4 SSMEM1 SYNPR TAAR9 TM4SF18 TMC4 TMEM179B TMEM237 TMEM248 TMEM31 TMEM45A TMEM52B TMEM69 TMEM71 TMEM80 TMEM9 TMPPE TTYH2 WFS1 YIPF6 ZDHHC4	32 interacting genes: ADRA1A ARRB1 ATP13A1 C4orf3 CLDN22 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR1 EMP1 FKBP8 GNA14 GNA15 GNAI2 GNAI3 GPRASP1 GRIA1 MYO5B PPBP PPP2CA RAB11FIP2 RGS12 SLC18A2 SLC39A2 SMCO4 ST13 TMEM147 TMEM80 TRARG1
Entrez ID		286753	3579
HPRD ID		18248	00907
Ensembl ID		ENSG00000184811	ENSG00000180871
Uniprot IDs		Q8IXB3	P25025 Q53PC4
PDB IDs			4Q3H 5TYT 6KVA 6KVF 6LFM 6LFO
Enriched GO Terms of Interacting Partners?
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