GPR22 and NFATC4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		GPR22	NFATC4
Description		G protein-coupled receptor 22	nuclear factor of activated T cells 4
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Chromatin Nucleus Transcription Regulator Complex Cytosol Nuclear Speck
	Molecular Function	G Protein-coupled Receptor Activity Peptide Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Transcription Factor Binding Peroxisome Proliferator Activated Receptor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Cell Projection Organization	Branching Involved In Blood Vessel Morphogenesis Cytokine Production Regulation Of Transcription By RNA Polymerase II Inflammatory Response Heart Development Long-term Memory Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Wnt Signaling Pathway Brain-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Protein Binding Positive Regulation Of Tumor Necrosis Factor Production Calcineurin-NFAT Signaling Cascade Cellular Response To UV Negative Regulation Of Chromatin Binding Negative Regulation Of Neuron Apoptotic Process Cellular Respiration Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Dendrite Morphogenesis Smooth Muscle Cell Differentiation Muscle Cell Development Long-term Synaptic Potentiation Cellular Response To Lithium Ion Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Synapse Maturation Positive Regulation Of Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Diastolic blood pressure ( 27841878) Height ( 20881960 25282103 23563607) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		3 interacting genes: CEBPE NFATC4 TFAP2C	12 interacting genes: CCNG1 CREBBP GATA4 GPR22 JUP MAPK14 MAPK8 MAPK9 NLGN3 NR1I2 YWHAQ YWHAZ
Entrez ID		2845	4776
HPRD ID		03552	09096
Ensembl ID		ENSG00000172209	ENSG00000100968
Uniprot IDs		B3KV13 Q3KNS9 Q99680	Q14934
PDB IDs			2YRP
Enriched GO Terms of Interacting Partners?
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