IFNL1 and IFNLR1

Number of citations of the paper that reports this interaction (PubMedID 12469119)
542

Data Source:
HPRD (in vivo)

		IFNL1	IFNLR1
Description		interferon lambda 1	interferon lambda receptor 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Interleukin-28 Receptor Complex	Plasma Membrane Integral Component Of Membrane Interleukin-28 Receptor Complex
	Molecular Function	Signaling Receptor Binding Cytokine Activity Interleukin-28 Receptor Binding	Cytokine Receptor Activity Protein Binding
	Biological Process	Negative Regulation Of Type 2 Immune Response Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Cell Population Proliferation Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-5 Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Memory T Cell Differentiation Innate Immune Response Positive Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of T Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Immune Response Defense Response To Virus	Mucosal Immune Response Negative Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Response To Type III Interferon Regulation Of Defense Response To Virus By Host Defense Response To Virus Positive Regulation Of Cellular Respiration
Pathways		Other interleukin signaling Interleukin-20 family signaling	Other interleukin signaling Interleukin-20 family signaling
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory skin disease ( 25574825) Molybdenum levels ( 26025379) Psoriasis vulgaris ( 26626624)
Interacting Genes		2 interacting genes: IFNLR1 VPS26C	7 interacting genes: ANKRD46 BRICD5 CTXN3 IFNL1 IFNL2 LSM8 PAEP
Entrez ID		282618	163702
HPRD ID		09588	09589
Ensembl ID		ENSG00000182393	ENSG00000185436
Uniprot IDs		Q8IU54	Q8IU57
PDB IDs		3OG4 3OG6	3OG4 3OG6 5IXD 5IXI 5L04 5T5W
Enriched GO Terms of Interacting Partners?
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