PPP2R3B and CDC6

Number of citations of the paper that reports this interaction (PubMedID 10629059)
35

Data Source:
BioGRID (two hybrid, affinity chromatography technology, pull down)
HPRD (in vivo, two hybrid, in vitro)

		PPP2R3B	CDC6
Description		protein phosphatase 2 regulatory subunit B''beta	cell division cycle 6
Image
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytosol	Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Intercellular Bridge Spindle Midzone Mitotic Spindle
	Molecular Function	Calcium Ion Binding Protein Binding Protein Phosphatase Regulator Activity	Nucleotide Binding DNA Replication Origin Binding Protein Binding ATP Binding Kinase Binding
	Biological Process	Protein Dephosphorylation Regulation Of Catalytic Activity Regulation Of Cell Cycle	DNA Replication Checkpoint Signaling Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mitotic Cell Cycle DNA Replication Initiation Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cytokinesis Mitotic DNA Replication Checkpoint Signaling Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Fibroblast Proliferation Cell Division Positive Regulation Of Chromosome Segregation Cellular Response To Vasopressin Cellular Response To Angiotensin
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition	Transcription of E2F targets under negative control by DREAM complex Activation of ATR in response to replication stress CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 G1/S-Specific Transcription
Drugs
Diseases
GWAS			Asthma ( 31619474)
Interacting Genes		11 interacting genes: CDC6 DUSP12 HGS NAA10 NOD2 PPP2CA PPP2R1A PPP2R1B SHANK3 SLC6A9 TMEM14B	40 interacting genes: AKAP8L ATM ATRIP B3GALNT1 CCNA2 CCNB1 CCNE1 CCNF CDC14A CDC20 CDK1 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDT1 DSC2 FZR1 KAT7 MCM10 MCM2 MCM3 MCM7 MYC OGT ORC1 ORC2 ORC3 ORC5 ORC6 PCNA PPP2R3A PPP2R3B PSKH1 RPS27A SQSTM1 TERF1 UBE2K UBR1
Entrez ID		28227	990
HPRD ID		02276	04022
Ensembl ID		ENSG00000167393	ENSG00000094804
Uniprot IDs		Q9Y5P8	A0A024R1S2 Q99741
PDB IDs		4I5L 4I5N 4MEW	2CCH 2CCI 4I5L 4I5N
Enriched GO Terms of Interacting Partners?
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