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STK39 and PRKCQ
Number of citations of the paper that reports this interaction (PubMedID
10980603
)
52
Data Source:
HPRD
(in vivo, in vitro)
STK39
PRKCQ
Description
serine/threonine kinase 39
protein kinase C theta
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Cytosol
Cytoskeleton
Basolateral Plasma Membrane
Apical Plasma Membrane
Extrinsic Component Of Membrane
Intracellular Membrane-bounded Organelle
Immunological Synapse
Cytosol
Plasma Membrane
Aggresome
Centriolar Satellite
Molecular Function
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Protein Kinase Binding
Protein Serine Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Kinase C Activity
Calcium-dependent Protein Kinase C Activity
Protein Binding
ATP Binding
Metal Ion Binding
Protein Serine Kinase Activity
Biological Process
Protein Phosphorylation
Signal Transduction
Regulation Of Blood Pressure
Positive Regulation Of T Cell Chemotaxis
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Positive Regulation Of Ion Transmembrane Transporter Activity
Intracellular Signal Transduction
Maintenance Of Lens Transparency
Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway
Positive Regulation Of Potassium Ion Transport
Protein Autophosphorylation
Regulation Of Inflammatory Response
Ion Homeostasis
Cellular Hypotonic Response
Negative Regulation Of Pancreatic Juice Secretion
Positive Regulation Of P38MAPK Cascade
Negative Regulation Of Potassium Ion Transmembrane Transporter Activity
Negative Regulation Of Potassium Ion Transmembrane Transport
Negative Regulation Of Creatine Transmembrane Transporter Activity
Cellular Response To Chemokine
Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Regulation Of Cell Growth
Immune System Process
Regulation Of Transcription, DNA-templated
Membrane Protein Ectodomain Proteolysis
Inflammatory Response
Axon Guidance
Peptidyl-serine Phosphorylation
Positive Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Interleukin-17 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-4 Production
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of T Cell Proliferation
Negative Regulation Of Insulin Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Telomerase Activity
Cell Chemotaxis
Negative Regulation Of T Cell Apoptotic Process
Regulation Of Platelet Aggregation
Positive Regulation Of Telomere Capping
Positive Regulation Of T-helper 17 Type Immune Response
Positive Regulation Of T-helper 2 Cell Activation
Pathways
Apoptotic cleavage of cellular proteins
Effects of PIP2 hydrolysis
Downstream TCR signaling
Inactivation, recovery and regulation of the phototransduction cascade
FCERI mediated NF-kB activation
FCERI mediated NF-kB activation
Netrin-1 signaling
G alpha (z) signalling events
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RAS processing
Drugs
Fostamatinib
Tamoxifen
Staurosporine
Phosphonothreonine
Dexfosfoserine
Fostamatinib
Diseases
GWAS
Blood pressure (
19114657
)
Body mass index (
28552196
28892062
)
Daytime nap (
33568662
)
Macular thickness (
30535121
)
Metabolite levels (
23823483
)
Parkinson's disease (
21292315
25064009
32201043
27182965
28892059
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Type 1 diabetes (
32005708
)
Weight (
28552196
)
Asthma (
31959851
30929738
)
Asthma (bronchodilator response) (
23508266
)
Asthma (childhood onset) (
31036433
30929738
)
Autoimmune traits (pleiotropy) (
30572963
)
Body mass index in asthmatics (
23517042
)
Celiac disease (
22057235
24999842
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Chronic pain (
33685280
)
Crohn's disease (
28067908
)
Factor VII activity (
30642921
)
Immune response to smallpox vaccine (IL-6) (
22542470
)
Medication use (thyroid preparations) (
31015401
)
Rheumatoid arthritis (
30423114
18794853
24390342
20453842
)
Rheumatoid arthritis (ACPA-positive) (
24532676
)
Type 1 diabetes (
19430480
18978792
)
Interacting Genes
15 interacting genes:
AATK
GSN
HSPH1
MAPK14
MBP
OTOF
PRKCQ
RELT
SLC12A1
SLC12A2
SLC12A6
SPP1
TSC22D2
WNK4
XRN2
28 interacting genes:
AKT1
BTK
CARD11
CASP3
CBL
CHUK
CISH
FYN
GATA3
GLRX3
GRM5
HABP4
ICAM3
IKBKB
IKBKG
IRS1
LCK
LYN
MARK3
MSN
RASGRP3
SELL
STK39
TAL1
VAV1
WIPF1
YWHAG
YWHAQ
Entrez ID
27347
5588
HPRD ID
09627
02710
Ensembl ID
ENSG00000198648
ENSG00000065675
Uniprot IDs
Q9UEW8
Q04759
PDB IDs
1XJD
2ENJ
2ENN
2ENZ
2JED
4Q9Z
4RA5
5F9E
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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