RABGEF1 and TEAD4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		RABGEF1	TEAD4
Description		RAB guanine nucleotide exchange factor 1	TEA domain transcription factor 4
Image
GO Annotations	Cellular Component	Nucleolus Early Endosome Cytosol Early Endosome Membrane Recycling Endosome	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	DNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Small GTPase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Protein Targeting To Membrane Endocytosis Regulation Of Catalytic Activity	Skeletal System Development Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Hippo Signaling Embryonic Organ Development
Pathways		TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs	YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription
Drugs
Diseases
GWAS		Aortic root size ( 21223598) Central corneal thickness ( 32528159 29760442)	Narcolepsy with cataplexy ( 23496005)
Interacting Genes		50 interacting genes: ABI2 ANKRD29 AP1G1 ARRDC3 BLOC1S6 CCHCR1 CDC37 CIPC DAZAP2 DCTN2 DGCR6 DNAJC5 EMILIN1 GGA1 GGA2 GPRASP2 HOOK2 HRAS IHO1 KXD1 MID2 MON1A MON1B OIP5 RAB33B RAB4A RABEP1 RAD23A RASAL3 RNF11 RNF168 RPS27A SESTD1 SNAPIN SPART SSX3 TCHP TEAD4 THOC1 TRIM15 TRIM54 TXN2 UBA52 UBB UBC UBE2D1 UBE2D3 WASHC1 YWHAB ZC2HC1C	50 interacting genes: CCDC125 CCDC172 CCDC85B CCNDBP1 CDR2 CEP55 CEP70 CTBP1 DYDC1 EXOC3-AS1 FBXO7 GOLGA2 GOLGA6L9 HAUS1 HOMEZ INCA1 KIAA0753 KRT27 KRT31 KRT40 KRTAP10-3 LDOC1 LZTS2 MDFI MTUS2 MYH7 NUTM1 PDE4DIP PFKM PNMA1 PRDM14 PRKAR1B RABGEF1 RASSF10 RUNDC3A RUNX1 SAT1 SESTD1 SORBS3 SSX2IP TLE5 TRAF1 TRIM27 TRIM54 VGLL1 VGLL3 VPS52 VTA1 WWTR1 YAP1
Entrez ID		27342	7004
HPRD ID		11477	03421
Ensembl ID		ENSG00000154710	ENSG00000197905
Uniprot IDs		A0A024RDL6 A8K3R3 B3KMF1 Q9UJ41	Q15561
PDB IDs		1TXU 2C7M 2C7N 2OT3 4N3X 4N3Y 4N3Z 4Q9U	5GZB 5NO6 5OAQ 6GE3 6GE4 6GE5 6GE6 6GEC 6GEE 6GEG 6GEI 6GEK 6HIK 6Q2X 6Q36 6SEN 6SEO
Enriched GO Terms of Interacting Partners?
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